Phenomenex, Inc.

***Live: Monday, November 9, 2020 at 11am EST| 8am PST| 4pm BST| 5pm CET *** Join us for this webcast to learn about sample preparation strategies for oligonucleotides bioanalytical workflows, including optimization of sample pre-treatment and solid-phase extraction for different types of oligonucleotides, how to approach extraction depending on different types of biological matrices, including solid tissue, and alternative sample preparation strategies using hybridization extraction. ***On demand available after final airing until Nov. 9, 2021***

***Live: Thursday, November 12, 2020 at 11am EST| 8am PST| 4pm GMT| 5pm CET*** What can you expect when moving to micro- and nano-scale HPLC? Join us for this webcast to learn about tools for micro- and nano-scale HPLC that are now available, in terms of new column technologies, injection modes (trap and elute), and separation condition strategies, and even connection systems that can help with the miniaturization of analytical scale separations to micro and nano scale. ***On demand available after final airing until Nov. 12, 2021***

IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) for better characterization of the Fc fragment.

This application combines cysteine proteases IgdE and IdeS, to observe conserved and hypervariable regions of the antibody, as well as identification of other variants.

IgdE allows for better characterization of the antibody and yields an intact Fc and an intact Fab fragment that can be further isolated and characterized.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection, separation of low-level impurities for subunit analysis.