Learn about aggregate and charge-variant analysis using native-mode MS Understand the fundamentals in SEC and IEX for biotherapeutic characterization Learn the effect of mobile-phase conditions and chromatographic parameters in aggregate analysis by native SEC
- ADCs can be analyzed using various methods other than the traditional HIC. - New chromatographic materials expand analytical techniques for APOC
• Improving sample preparation improves sensitivity and reliability • Using a high-capacity paramagnetic bead solution to clean up & isolate mAbs • Optimize clean-up of labeling reagent, salts, or surfactants pre-analysis
Chromatographic analyses of antibody-drug conjugates using various techniques including SEC, reversed phase, and ion-exchange chromatography. Learn about method development for these techniques from our expert at Phenomenex. Live: Tuesday, Oct. 15, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST On demand available after final airing Oct. 15, 2020 Register free
• Analyzing biogenic amines in food by adding ion-paring agents • Case studies on polar aminoglycosides; paraquat/diquat; and BAs in food
• 4D LC offers significant benefits for biotherapeutic characterization. • Multidimensional LC can help find previously undetected impurities. • User-friendly software offers a solution to 4D-LC challenges.
Register today to expand your knowledge of solid phase extraction and how to adopt new SPE technologies into your current workflow. Updating to easier and faster methods can help to provide better recovery and clean results. Live: Tuesday, Sept. 24, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST On demand available after airing until Sept. 24, 2020 Register free
Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.
Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.
Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.
This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.
When working with milk as a matrix, Strata-X PRO SPE removes phospholipids more efficiently than traditional SPE to reduce any ion suppression that may occur during LC-MS/MS analysis.
Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.
When working with milk as a matrix, Strata-X PRO SPE removes phospholipids more efficiently than traditional SPE to reduce any ion suppression that may occur during LC-MS/MS analysis.
This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.
Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.
In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.
For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.
In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.
For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.
Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.
• Applications of native mass spectrometry • Implementation and technical challenges with native MS
Register today to expand your knowledge of new and unique single- and multi-dimensional GC method for detailed hydrocarbon analysis (DHA), PIONO and PONA analysis. Learn how optimizing the selection of your GC columns can help improve the method run time and sensitivity of your analytical methods, making the GC column selection a less painful proposition. Live: Thursday, Sept. 12, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST On demand available after airing until Sept. 12, 2020 Register free
In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.
In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.
In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.
In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.
This application note serves to highlight how native MS can be used to get intact mass for non-covalently linked large molecules, including cysteine linked ADCs
