When working with complex matrices such as personal care products, sample preparation is perhaps the most difficult step of the analysis process. By utilizing a targeted sample preparation technique, such as ion-exchange SPE, analysis can be significantly improved as compared to less targeted techniques such as liquid-liquid extraction.
A new 3.6 µm 100 Å HPLC–UHPLC column (Aeris PEPTIDE) has been introduced that is specifically designed to improve separations of peptide and peptide mapping applications.
A new widepore core-shell HPLC–UHPLC column (aeris WIDEPORE) has been introduced that is specifically designed to improve protein separations.
This study demonstrates a faster method of analysis when coupling a simplified and effective SPE procedure with a core-shell HPLC column and LC–MS-MS detection.
Barbiturates are a class of antidepressants whose abuse and addiction by recreational users has become a widespread problem (www.nlm.nih.gov). In our work we strived to streamline the barbiturate screening process to provide a fast, cost-effective, and reproducible method from start to finish for forensic labs who are involved in high-throughput processing.
The chiral analysis and purification of proton pump inhibitors (PPIs) has become a popular topic as more of these drugs fall out of patent protection each year. Due to their wide range of enantiomeric selectivity, a set of polysaccharide-based chiral stationary phases (CSPs) was screened to identify methods for the successful enantioseparation of four benzimidazoles; rabeprazole, lansoprazole, omeprazole, and pantoprazole.
This study evaluates the performance of a C18 core-shell phase that incorporates a C18 ligand with iso-butyl side chains. The Kinetex? XB-C18 HPLC/ UHPLC column delivers a fast and effective separation of several common preservatives in cosmetics.
Due to the increasing number of toxic pesticides being used throughout the world, a robust method for positively identifying low levels of multiple classes of pesticides is required. A Zebron? ZB-MultiResidue? column is used with GC–MS to identify over 100 common pesticides.
Testosterone was extracted from human serum by strong anion exchange polymeric SPE and analyzed using a Kinetex C18, 30 ? 2.1 mm, 1.7 ?m column and positive polarity ESI LC–MS-MS system. Kinetex sub-2 ?m core-shell technology offers higher efficiencies than traditional sub-2 ?m columns, producing greater chromatographic resolution, sensitivity, and higher peak capacities.
