The Application Notebook-03-01-2019

In the present study, a novel GC–MS TQ method was developed and validated for the simultaneous analysis of 2-MCPD, 3-MCPD, and glycidyl fatty acid esters in edible oil. This method was subsequently applied to quantitation of these contaminants in commercial edible oil samples.

In this study, we aimed to use a charge modulated HILIC stationary phase (iHILIC®-Fusion) to separate different siderophores of the Pseudomonas taiwanensis VLB120 bacteria.

This application note outlines a simple three-step method for the extraction of loperamide and its main metabolite, N-desmethyl loperamide, from blood. UCT’s Clean Screen® XCEL I column provides users with the same level of sample clean-up as traditional SPE while allowing the elimination of timely conditioning and wash steps.

The Application Notebook
Pharmaceutical/Drug Discovery

March 01, 2019

For your highly sensitive UHPLC–MS analyses, how can you reduce noise and additional signals to a minimum?

The Application Notebook
Pharmaceutical/Drug Discovery

March 01, 2019

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a crucial mechanism of action (MoA) of anti-tumour therapeutic antibodies and FcγIIIa receptor plays a key role in this process by interacting with the N-glycans of IgG Fc regions. Hence, affinity chromatography on Fc receptor ligands can deliver valuable information about expected ADCC activity and mAb glycoform distribution.

The Application Notebook

This application note shows how to achieve robust chromatographic results for two commercially available mAbs: Adalimumab (Humira®) and Bevacizumab (Avastin®).

The Application Notebook

Branching affects macroscopic polymer properties such as crystallinity, melting temperature, toughness, ductility, and optical clarity. Two types of branching are long-chain branching (LCB) and short-chain branching (SCB), wherein the molar mass of the branches is larger or smaller than the entanglement molar mass, respectively.