February 2022 | LCGC Europe

Hydrophilic-Phase Extraction: A New Avenue of Solid-Phase Extraction for Oligonucleotide Bioanalysis

February 01, 2022

Peer Reviewed

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A novel approach using hydrophilic-phase extraction (HPE) for the analysis of oligonucleotides in bioanalysis applications is described. The HPE method was proven to be a critical part of a fully quantitative HILIC–high-resolution mass spectrometry (HRMS) method for the RNA oligonucleotide and has potential for general application.

The Current Status of Metal-Organic Frameworks (MOFs) for Use in LC

February 01, 2022

Column Watch

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Due to the enormous interest in a 2018 “Column Watch” article on the subject and the high level of research in the field, this article explores recent (2019–present) activity specifically towards the application of MOFs for liquid chromatography.

How Static Are Static Data?

February 01, 2022

Questions of Quality

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A balance printout is a fixed record, and is also called static data. But how static are static data when the weight is used in a chromatographic analysis? Also, have some regulatory data integrity guidance documents failed to comply with their own regulations?