July 2021 | LCGC Europe

Low-Level Determination of Mutagenic Nitrosamine Impurities in Drug Substances by LC–MS/MS

July 12, 2021

Peer Reviewed

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This article discusses the development of a series of applications that will allow for the determination of a number of nitrosamines that have been identified by the FDA as genotoxins to monitor, initially showing how to perform a separation of these compounds from the API and then looking at how MS can be applied to the analysis to ensure that the required detection limits can be reached.

Fast GC–MS for Analyzing Antioxidants and Industrial Food Analysis Applications

July 12, 2021

Food Analysis

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LCGC Europe spoke to Hans-Gerd Janssen from the Unilever Foods Innovation Centre in The Netherlands, about the advantages of a novel, rapid method to analyze antioxidants that inhibit oxidation, and he explains that the maturity of GC technology is actually an advantage to the analyst.

Hard-Won Lessons in GC

July 12, 2021

GC Connections

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The May 2021 ChromTalks, presented by LCGC and CHROMacademy, brought together 12 world-renowned chromatography experts discussing some of the most important lessons and experiences that shaped their careers. This month, we look back at ChromTalks and share the lessons learnt from these great speakers, with topics including sample preparation, GC, and GC–MS.

Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part 3: Tubing and Detectors

July 12, 2021

LC Troubleshooting

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In recent articles, the authors reviewed the basic concepts of extracolumn dispersion and how this phenomenon can impact the quality of an LC separation. We now specifically discuss the effects of dispersion that can occur due to tubing and detectors.

Recent Developments in Open-Tubular LC Columns

July 12, 2021

Column Watch

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Recent developments in open-tubular liquid chromatography (OTLC) are explored with an emphasis on advances in column technology.