LCGC North America-06-01-2002

This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients.

John Hinshaw examines the principal safety issues surrounding the handling and use of compressed gas cylinders.

John Dolan focuses on several aspects of column temperature, which can affect retention, selectivity, peak shape, and column pressure.

The authors suggest ways to avoid phase collapse and regenerate collapsed phases.