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The first presentation will be given by Roxana E. Iacob of Northeastern University and will discuss the influence of adnectin on the extracellular domain of epidermal growth factor receptor (EGFR) as measured by hydrogen?deuterium exchange mass spectrometry.

Yinsheng Wang of the University of California, Riverside, has focused his research on discovering the biological consequences of DNA damage and on unraveling mechanisms of action for anti-tumor drugs and environmental toxicants.

This session will cover a broad range of emerging environmental contaminants including organic components from fire retardant applied during a wildfire, disinfectant byproducts in swimming pools, pharmaceuticals in wastewater samples, and more.

Exhibitor Highlights

Welcome to Amsterdam

Among the 11 conference workshops taking place Tuesday from 5:45 to 7:00 p.m. is ?LC-MS in the Clinical Lab: How Close is 24/7?? which was organized by the Clinical Chemistry Interest Group and will have Brett Holmquist and Cory Bystrom presiding.

This session includes presentations of quantitative studies performed using mass spectrometry techniques for applications ranging from breast cancer biomarkers to site-specific protein glycosylation to therapeutic oligonucleotides.

The first talk in this session titled ?Integrated Quantitative and Qualitative work-flow for In-vivo Discovery Bioanalysis using Hybrid Quadrupole-Time-of-Flight Mass Spectrometry? will be given by Asoka Ranasinghe of Bristol-Myers Squibb Company.

Monday afternoon?s six presentations will focus on dried blood spot analysis, including the development of enzyme assays based on tandem mass spectrometry for the detection of lysosomal storage disorders; analysis of hemoglobin peptides in tryptic digests of dried-blood spot extracts; in-paper dried blood spot enzyme assays to determine plasma enzyme activities; the determination of neonatal paraben exposure; the introduction of a ?detergent-assisted elution? to improve analyte elution efficiency in dried matrix spot bioanalytical assays by UHPLC?MS-MS; and a method to quantify peptides from insulin-like growth factor-1 and its synthetic analogues in dried blood spots by LC?MS-MS.

Floor Plan

LCGC's 2013 Emerging Leader in Chromatography award winner Davy Guillarme, a senior lecturer at the University of Geneva, University of Lausanne, in Geneva, Switzerland, recently spoke to us about how his career began and where his research is leading him now.

Scientists from the Karolinska Institute (Stockholm, Sweden) have taken a step closer towards the development of portable illicit drug testing using exhaled breath.1 The study published in the Journal of Breath Research details the use of liquid chromatography?mass spectrometry (LC-MS) to analyse exhaled breath of patients recovering from acute drug abuse.

The nature of retention time changes in HPLC tends to fall into categories. Firstly, the retention time may "drift" over several injections or several analytical campaigns and secondly, the retention time may suddenly "jump to a different value between injections or between analytical campaigns (i.e. analyte retention times are very different to when that method was run last).

Malvern Instruments (Malvern, UK) has entered a three year co-marketing agreement with Netzsch Grinding and Dispersing (Selb, Germany). The two companies serve shared markets including food, ceramics, pharmaceuticals, nano-technology applications, and surface coatings through to metal and mineral mining.

Two researchers from the University of New England in Armidale, Australia, have investigated the traditional medicines used in Australian Aboriginal cultures using gas chromatography- mass spectrometry (GC-MS) and gas chromatography with flame ionization detection (GC-FID).1

A group of collaborating researchers in Brazil has increased the instrumental throughput of a gas chromatography-flame ionization detection (GC-FID) method by a factor of 2.6 without instrumental modification.1

Larry Miller, Green Chemistry Group, Oakmont, Pennsylvania, USA. The 7th annual International Conference on Packed Column SFC will take place at the Boston Convention and Exhibition Center, Boston, Massachusetts, USA, from 10-12 July 2013.

The affinity and absolute stoichiometry of interactions between a DNA aptamer and a tetrameric target is quantified using CG-MALS is discussed.

The Column spoke to John Points from LGC about analysing veterinary residues in the food chain, the role of the National Reference Laboratory, and recent food scares in the media.

GPC/SEC analysis can be easily optimized to yield improved results when analysing oligomers and low molar mass macromolecules.

Questions about how practical proposed gas chromatography (GC) method changes are often come up during optimization for speed and resolution, or while converting to a different carrier gas. Related objective measurements such as the optimum practical carrier gas velocity were defined more than 40 years ago. This instalment reviews such metrics in the light of their relevance to today's GC challenges.

The frequency of recognition of toxic drug residues is an important issue concerning emerging environmental contaminants. This problem is also exacerbated by the low therapeutic index of drugs used in cancer chemotherapy.

Application Note

This analysis offers insight for optimizing the structure of monoliths.

Profiles of Peter W. Carr, the Lifetime Achievement in Chromatography award winner, and Davy Guillarme, the Emerging Leader in Chromatography winner.

For the next improvements, we must look beyond the column.

Application Note

Fasha Mahjoor, CEO of Phenomenex (Torrance, California), has been awarded an Ellis Island Medal of Honor.