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This article looks at how hydrogen-deuterium exchange mass spectrometry (HDX-MS), an MS-based labelling approach, has begun to serve as a means for performing routine biophysical analysis.

The authors describe a simple and fast quantification method to determine capsaicinoids in hot sauces extracted from a wide range of sources, including hot sauces and sausages.

Problems with the chromatogram can often reveal underlying problems with methods or instrumentation and learning to recognize and fix these problems is essential for all chromatographers.

For more than 40 years, he has been a master communicator. That's just one reason he has so many fans, and friends, around the world.

The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of this impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.

HDX-MS as a means for performing routine biophysical analysis

Click the title above to open the LCGC Asia Pacific June 2013 regular issue, Vol 16, No 2, in an interactive PDF format.

Click the title above to open the LCGC Europe June 2013 regular issue, Vol 26 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2013 regular issue, Vol 31 No 6, in an interactive PDF format.

The National University of Singapore Environmental Institute (NERI), and Thermo Fisher Scientific are collaborating on a project to monitor and improve water quality in Singapore. LCGC spoke to the scientists involved to find out more about the project.

The physical characteristics of silica-based HPLC columns can affect the performance of the separation almost as much as the bonded phase. This month's technical tip re-visits some of the lesser known or remembered facts relating to silica particles used for chromatography.

Click here to view the full LCGC Europe E-newsletter from 31 May

Agilent Technologies (Santa Clara, California, USA) has teamed up with the Glyco-MEV laboratory at the University of Rouen (Rouen, France) and the Bioprocessing Technology Institute (BTI) at the Agency for Science, Technology and Research (A*STAR) (Singapore) to sign a memorandum of understanding to develop tools to analyse biologics and vaccines.

The preservation of food at home is a major concern for all consumers. A group of researchers from INRA in Avignon, France, have conducted a study into tomato aroma with the aim of finding the optimum conditions for storage. According to results published in Food Chemistry,1 the team used gas chromatography coupled to mass spectrometry (GC?MS) to measure volatile compounds in the fruit.

Agilent Technologies (Santa Clara, California, USA) has teamed up with the Glyco-MEV laboratory at the University of Rouen (Rouen, France) and the Bioprocessing Technology Institute (BTI) at the Agency for Science, Technology and Research (A*STAR) (Singapore) to sign a memorandum of understanding to develop tools to analyse biologics and vaccines.

Fasha Mahjoor, CEO of Phenomenex (Torrance, California, USA), has been awarded an Ellis Island Medal of Honor. The awards are given annually by the National Ethnic Coalition of organizations (NECO) in recognition of leaders who are philanthropic, who preserve and celebrate the values of their ancestry group, and who promote tolerance and acceptance.

Malvern Instruments (Malvern, UK) has entered a three year co-marketing agreement with Netzsch Grinding and Dispersing (Selb, Germany). The two companies serve shared markets including food, ceramics, pharmaceuticals, nano-technology applications, and surface coatings through to metal and mineral mining.

As Quality by Design has become a more established approach in pharmaceutical development and manufacturing, more companies are now integrating the concept into analytical method development. LCGC spoke to Rosario LoBrutto of Teva about the business of analytical QbD, the steps involved in implementing it, and advice to those who want to get started.

Two researchers from the University of New England in Armidale, Australia, have investigated the traditional medicines used in Australian Aboriginal cultures using gas chromatography?mass spectrometry (GC?MS) and gas chromatography with flame ionization detection (GC?FID).1

A team of scientists from Stockholm University in Sweden has developed a method for screening and determining drugs in human saliva using microextraction by packed sorbent (MEPS) and liquid chromatography tandem mass spectrometry (LC?MS?MS).1

Click here to view the complete LCGC Europe E-Newsletter from 17 May 2013

Dr Jindan Yu, assistant professor of medicine at Northwestern University (Illinois, USA), received the Agilent Early Career Professor Award from Agilent Technologies (California, USA). Yu will direct $100,000 of research funding from Agilent.

The preservation of food at home is a major concern for all consumers. A group of researchers from INRA in Avignon, France, have conducted a study into tomato aroma with the aim of finding the optimum conditions for storage. According to results published in Food Chemistry,1 the team used gas chromatography coupled to mass spectrometry (GC?MS) to measure volatile compounds in the fruit.

By implementing automation, a laboratory can instantly increase throughput, improve accuracy, reproducibility, and lab-to-lab consistency.

Agilent Technologies (California, USA) has opened the Asia Glycomics Education Center in South Korea, building on the recent collaboration with Chungham National University (Daejon, South Korea) through the university's Graduate School of Analytical Science and Technology (GRAST).

Consumer protection requires that harmful chemicals are prevented from reaching food products or pharmaceuticals designated for human consumption. Packaging keeps products fresh and protects against direct contamination; however, materials used to manufacture the packaging can be an unintended source of migrating chemicals. To perform routine migration studies, food producers, or packaging suppliers, need to determine barrier properties of primary food packaging.

Incognito dreams of a future with a completely intuitive and flexible data system.

An international team of scientists led by Dr Oliver Craig, University of York (York, UK) has published evidence for the consumption of fish by hunter-gatherers in the last ice age in the journal Nature.1