All News

The affinity and absolute stoichiometry of interactions between a DNA aptamer and a tetrameric target is quantified using CG-MALS is discussed.

The Column spoke to John Points from LGC about analysing veterinary residues in the food chain, the role of the National Reference Laboratory, and recent food scares in the media.

GPC/SEC analysis can be easily optimized to yield improved results when analysing oligomers and low molar mass macromolecules.

Questions about how practical proposed gas chromatography (GC) method changes are often come up during optimization for speed and resolution, or while converting to a different carrier gas. Related objective measurements such as the optimum practical carrier gas velocity were defined more than 40 years ago. This instalment reviews such metrics in the light of their relevance to today's GC challenges.

The frequency of recognition of toxic drug residues is an important issue concerning emerging environmental contaminants. This problem is also exacerbated by the low therapeutic index of drugs used in cancer chemotherapy.

Application Note

This analysis offers insight for optimizing the structure of monoliths.

Profiles of Peter W. Carr, the Lifetime Achievement in Chromatography award winner, and Davy Guillarme, the Emerging Leader in Chromatography winner.

For the next improvements, we must look beyond the column.

Fasha Mahjoor, CEO of Phenomenex (Torrance, California), has been awarded an Ellis Island Medal of Honor.

The first instalment of the Perspectives in Modern HPLC column highlights some of the new HPLC systems, accessories and related technology introduced at Pittcon this year.

This article looks at how hydrogen-deuterium exchange mass spectrometry (HDX-MS), an MS-based labelling approach, has begun to serve as a means for performing routine biophysical analysis.

The authors describe a simple and fast quantification method to determine capsaicinoids in hot sauces extracted from a wide range of sources, including hot sauces and sausages.

Problems with the chromatogram can often reveal underlying problems with methods or instrumentation and learning to recognize and fix these problems is essential for all chromatographers.

For more than 40 years, he has been a master communicator. That's just one reason he has so many fans, and friends, around the world.

The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of this impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.

HDX-MS as a means for performing routine biophysical analysis

Click the title above to open the LCGC Asia Pacific June 2013 regular issue, Vol 16, No 2, in an interactive PDF format.

Click the title above to open the LCGC Europe June 2013 regular issue, Vol 26 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2013 regular issue, Vol 31 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2013 Application Notebook, Vol 31 No s6, in an interactive PDF format.

The National University of Singapore Environmental Institute (NERI), and Thermo Fisher Scientific are collaborating on a project to monitor and improve water quality in Singapore. LCGC spoke to the scientists involved to find out more about the project.

The physical characteristics of silica-based HPLC columns can affect the performance of the separation almost as much as the bonded phase. This month's technical tip re-visits some of the lesser known or remembered facts relating to silica particles used for chromatography.

Click here to view the full LCGC Europe E-newsletter from 31 May

Agilent Technologies (Santa Clara, California, USA) has teamed up with the Glyco-MEV laboratory at the University of Rouen (Rouen, France) and the Bioprocessing Technology Institute (BTI) at the Agency for Science, Technology and Research (A*STAR) (Singapore) to sign a memorandum of understanding to develop tools to analyse biologics and vaccines.

The preservation of food at home is a major concern for all consumers. A group of researchers from INRA in Avignon, France, have conducted a study into tomato aroma with the aim of finding the optimum conditions for storage. According to results published in Food Chemistry,1 the team used gas chromatography coupled to mass spectrometry (GC?MS) to measure volatile compounds in the fruit.

Agilent Technologies (Santa Clara, California, USA) has teamed up with the Glyco-MEV laboratory at the University of Rouen (Rouen, France) and the Bioprocessing Technology Institute (BTI) at the Agency for Science, Technology and Research (A*STAR) (Singapore) to sign a memorandum of understanding to develop tools to analyse biologics and vaccines.

Fasha Mahjoor, CEO of Phenomenex (Torrance, California, USA), has been awarded an Ellis Island Medal of Honor. The awards are given annually by the National Ethnic Coalition of organizations (NECO) in recognition of leaders who are philanthropic, who preserve and celebrate the values of their ancestry group, and who promote tolerance and acceptance.