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Anthocyanins are a sub-class of naturally electron deficient and powerful antioxidants called flavonoids that are responsible for the red, orange, and blue coloration in fruits and flowers.

Tea, one of the most consumed non-alcoholic drinks worldwide, contains catechins that are powerful antioxidants thought to provide many health benefits, including reduction of cholesterol and obesity, and protection against cardiovascular disease and cancer.

PCBs are a group of synthetic organic chemicals that contain 209 individual compounds (known as congeners) with varying harmful effects. PCBs enter the environment as mixtures containing a variety of individual components.

High performance time-of-flight mass spectrometry (TOF-MS) is applied to the analysis and characterization of complex biological samples. High mass accuracy, high resolution, and accurate relative isotope abundance are all applied to the determination of analytes covering a range of concentrations in complex matrices including plasma and urine. Qualitative and quantitative evaluations are provided and include demonstrations of the impact of high-performance MS on sensitivity and selectivity. The ability to leverage high-performance MS in conjunction with a broad dynamic range in rapid ultrahigh-pressure liquid chromatography (UHPLC) analyses to identify unknowns and to propose putative metabolic biomarkers is demonstrated. The impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.

Waters Application Note

Glyphosate is a broad-spectrum herbicide widely used around the world. Monitoring of glyphosate in crops and water is mandated in many countries.

A new series on valves and the pivotal role they play in gas chromatography.

This study evaluates the performance of a C18 core-shell phase that incorporates a C18 ligand with iso-butyl side chains. The Kinetex? XB-C18 HPLC/ UHPLC column delivers a fast and effective separation of several common preservatives in cosmetics.

Due to the increasing number of toxic pesticides being used throughout the world, a robust method for positively identifying low levels of multiple classes of pesticides is required. A Zebron? ZB-MultiResidue? column is used with GC–MS to identify over 100 common pesticides.

Testosterone was extracted from human serum by strong anion exchange polymeric SPE and analyzed using a Kinetex C18, 30 ? 2.1 mm, 1.7 ?m column and positive polarity ESI LC–MS-MS system. Kinetex sub-2 ?m core-shell technology offers higher efficiencies than traditional sub-2 ?m columns, producing greater chromatographic resolution, sensitivity, and higher peak capacities.

The Consumer Product Safety Improvement Act of 2008 (CPSIA) requires testing of child care products and toys for selected phthalate esters by GC–MS.

Optical fibers are routinely used in liquid chromatographic detectors as a means of simplifying optical designs. Selection of the appropriate fiber is an important factor in achieving optimal system performance.

With advances in instrumentation and without regulatory method constraints, 1,4-dioxane can be detected at the part-per-billion (ppb) level, despite its poor purge efficiency. This application will manipulate purge and trap, as well as GC–MS parameters, to create a more efficient method to reduce cycle times. This study will utilize a Teledyne Tekmar Atomx Automated Sample Prep System in conjunction with an Agilent 7890/5975 GC–MS. A linear calibration and method detection limits (MDLs) for 1,4-dioxane will be established using this method.

Vitamin D deficiency has become a topic of interest in recent publications (1–3). Vitamin D is present in two forms, Vitamin D3 and Vitamin D2. D3 is produced after ultraviolet light-stimulated conversion of 7-dehydrocholesterol in the skin (3).

Kanamycin and amikacin are aminoglycoside antibiotics used to treat serious bacterial infections. Amikacin is used for infections resistant to other aminoglycosides because it is less susceptible to enzymatic reactions.

Coping with extractables and leachables testing is easier when you have a good understanding of the issues involved. Information from public databases and industry consortia also is invaluable.

Click the title above to open the LCGC North America June 2011 regular issue, Vol 29 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2011 Application Notebook, Vol 29 No s6, in an interactive PDF format.

Gyula Vigh, professor of chemistry and holder of the Gradipore Chair of Separation Science at Texas A&M University, has been selected as the 2011 recipient of the Hungarian Society for Separation Sciences (HSSS) Halász Medal Award recognizing research excellence in the separation sciences.

Claind, Italian manufacturer of gas generators has appointed Jaytee Biosciences as the sole distributor and service agent for their Brezza range of gas generators in the UK and Ireland.

LECO Product Profile

The N-methylcarbamates and the N-methylcarbamoximes are among the most widely used pesticides in agriculture. Dionex has announced an improved HPLC method for the determination of these chemicals.

The Open University and Agilent Technologies UK have announced the launch of the Agilent Centre of Excellence in Comprehensive Chromatography.

Researchers in Japan have found a way to separate nanometre-sized particles in a water-filled capillary using a laser-induced shockwave.

Thermo Fisher Scientific has announced the completion of its tender offer for Dionex Corporation.

Showa Denko and its consolidated subsidiary Shoko have decided to integrate their businesses in high-performance liquid chromatography (HPLC).

Dafydd Milton and Bob Wiedemer of Thermo Fisher Scientific spoke to us about how analytical laboratories have had to adapt to meet the changing needs of our times.

Peak product profile