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Pall product profile

American researchers say that they have found strong evidence to support the possibility of the seeds of life being brought to Earth by meteorites.

Click here to view the complete e-Separation Solutions newsletter from April 14, 2011.

James W. Jorgenson of the University of North Carolina at Chapel Hill received the 2011 LCGC Lifetime Achievement award. We spoke to him to talk about his work and his thoughts about the future of chromatography.

Waters NA - Diastereoselective Separation of Permethrin Using the ACQUITY UPSFC System

Little is known about the role of selective attention in odour discrimination, which is why a group from Japan has assessed whether mice can discriminate between different liquors, just like a wine expert.

Tosoh Profile

Lablogic has installed a Flow-RAM gamma radio HPLC detector for PET and SPECT at Imperial College's Hammersmith Hospital Campus in London, UK.

LGC Standards has opened a new facility at Chamberhall Green, Bury, UK. The new, purpose-built site will provide a centre of excellence for the operation of the company?s proficiency testing service.

Phenomenex NA - Faster Real-time Response to Bacterial Infection of Bioethanol Fermentation using a Short, Ion Exclusion Rezex? ROA Column

Phenomenex EU - Faster Real-time Response to Bacterial Infection of Bioethanol Fermentation using a Short, Ion Exclusion Rezex? ROA Column

A collaboration has been agreed between AB SCIEX and Alturas Analytics to accelerate the adoption of dried blood spot analysis for drug discovery and development.

Click here to view the complete e-Separation Solutions newsletter from April 7, 2011.

Thermo Fisher Scientific has announced a new method for the detection and absolute quantification of metabolites based on the company?s TSQ Quantum XLS in multiple reaction mode.

LCGC has announced the winners of the 4th Annual Emerging Leader and Lifetime Achievement in Chromatography Awards.

The Pittcon Editors? Awards have been awarded to the products judged to be the most innovative at the show. The gold award was shared by the LECO Citius LC–HRT and the WITec True Surface Microscopy Raman spectrometer.

Upcoming Events

Many GPC/SEC set-ups provide molar masses and molar mass distributions based on evaluation with a molar mass calibration curve created using molar mass reference standards.

Many laboratory budgets do not allow the purchase of new ultrahigh-pressure liquid chromatography (UHPLC) systems, and workloads typically are not declining. Fast LC incorporates the use of faster mobile phase flow rates and smaller particles to achieve separations in less time and with equivalent resolution to traditional high performance liquid chromatography (HPLC).

BioTek Instruments has established BioTek Korea, which the company reports will focus on growing the brand, and expanding direct service and application support for customers in South Korea.

William W. Carson, Ming Zhou, and Tom Kearney

Published methods for the determination of ibuprofen in biological fluids by liquid chromatography (LC)–UV or LC–mass spectrometry (MS)-MS have quantitation ranges consistent with the relatively high but typical ibuprofen dose (200–800 mg), generally having lower limits of quantitation in the low micrograms-per-milliliter range. For the analysis of plasma and synovial fluid samples from preclinical (miniature swine) studies utilizing a novel ibuprofen dosage form, LC–MS-MS methods were developed and validated over the 10–1000 ng/mL range. Ibuprofen undergoes biotransformation to ibuprofen acyl glucuronide and sublimes under routine bioanalytical sample handling conditions. Procedures were implemented to minimize the impact of these potential liabilities.

New chromatography technology for the analytical laboratory is being driven by the ever expanding need and challenge to get more and better information faster, all in an economic climate where cost control is a primary concern. At the same time, samples have become more and more complex, detection limits are being driven increasingly lower, and regulatory concerns, particularly for biotherapeutics, are being increasingly scrutinized.

As the debate over the budget for Fiscal Year 2011 continues, questions regarding plans for increased science funding in 2012 linger.

Screening with multiple orthogonal HPLC methods provides a comprehensive alternative to single method drug impurity profiling with their complementary selectivity. One key challenge of the approach is to track the peaks across the orthogonal chromatograms and identify all unique impurities.

High performance liquid chromatography (HPLC) with light absorbance detection (UV) is limited by the dependence of detector response on the structure of the analyte. Some detection techniques based on nebulization of the mobile phase and formation of Aerosol particles demonstrate an analyte independent response that approaches "universal."

Agilent Product Profile

A fast, selective, and reproducible high performance liquid chromatography (HPLC) method was developed and validated for the analyses of third-generation cephalosporin antibiotics, namely, ceftriaxone, cefixime, and cefdinir in human plasma. The analysis was carried out on a 150 mm Ã- 4.6 mm, 5.0-µm C18 column. The mobile phase used was 80:20 (v/v) 50 mmM phosphate buffer (pH 5.0)–methanol at a flow rate of 1.0 mL/min with 230-nm UV detection.