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The UK's Institute of Cancer Research is collaborating with scientists at AB SCIEX to standardize advanced methods of mass spectrometry-based tissue imaging.

Using liquid chromatography-tandem mass spectrometry (LC-MS-MS) to examine the role of quorum sensing on an endophytic strain of Serratia.

This month's column examines important aspects of solvent selection and how this affects selectivity.

Capillary Electrophoresis is useful for analysing simple inorganic anions in forensic, clinical and pharmaceutical applications.

Waters Application Note

If the art of method development is dying what can we do about it?

Spark Holland Application Note

A new series on valves and the pivotal role they play in gas chromatography.

Dionex Application note

Thermo Fisher Scientific has launched a YouTube channel dedicated to chromatography videos. The first two videos uploaded provide educational information on the mechanics of GC and sample preparation.

Most plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.

The inclusion of time-resolved selected reaction monitoring (SRM) functionalities into mass spectrometer control software allows large numbers of peptides to be quantified using short LC–MS-MS methods.

The metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.

Increases in vitamin D testing frequency have required more rapid and cost-effective solutions for determining vitamin D levels in plasma. This LC–MS method was adapted for use with core-shell columns to achieve run times of less than 4 min.

PSS Application Note

There are many enjoyable aspects to my role here at LCGC. None rivals the pride, however, I feel in announcing the winners of the 2011 LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards.

Fossilomics uses MS to extract amino acid sequence information from subpicomole quantities of protein and peptide fragments that remain in certain fossil samples. The sequences are compared to databases and validated with search statistics and high-confidence sequences. The validated sequences can then be used to place the fossils on the evolutionary tree.

Sample preparation is one of the most critical steps of the development and application of an analytical methodology.

Researchers have used gas chromatography-mass spectrometry to study the scent of the Cytinus visseri and its effect on animals.

For this month's Chromatography Corner, we spoke to Kevin Schug of the University of Texas at Arlington. Schug addresses a few myths that surround electrospray ionization (ESI), including why "less is more" for successful separations.

Click the title above to open the LCGC North America March 2011 regular issue, Vol 29 No 3, in an interactive PDF format.

Click the title above to open the March 2011 issue of Current Trends in Mass Spectrometry, Volume 9, Number 1, in an interactive PDF format.

Researchers have used gel filtration chromatography and fast protein liquid chromatography to analyze the genes and molecular mechanisms that allow mice to resist developing obesity.

Trimega Laboratories has opened a new lab in Manchester, UK that will be used to assist the government with its forensic toxicology workload in the wake of the closure of the Forensic Science Service.

In response to a recent discovery of dioxins in animal feed produced in Germany, Phenomenex has published a new method for the analysis of dioxins in animal feed and tissue using high-resolution gas chromatography with mass spec detection (HRGCMS).

In its simplest form the process of mass analysis in LC-MS involves the separation or filtration of analyte ions.

For this month's Chromatography Corner, we spoke to Kevin Schug of the University of Texas at Arlington. Schug addresses a few myths that surround electrospray ionization (ESI), including why "less is more" for successful separations.