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News All the news from February 2006 Opinion Zosimus voices his confusion ocer choosing silica and asks why so many brands are available. Market Trends & Analysis Glenn Cudiamat looks at the increasing demand for capillary electrophoresis systems particularly in the biotech and pharmaceutical industries. A new system for high-temperature gradient HPLC of polymers L.C. Heinz, T. Macko, A. Williams, S. O'Donohue and H. Pasch Selective extractions by molecularly imprinted polymers Christine Widstrand, Ecevit Yilmaz, Brian Boyd and Anthony Rees Country focus Find out about the latest developments in the UK and Benelux. Q&A Helmut Schulenberg-Schell, LC marketing manager of Agilent Technologies, talks to The Column about the company's latest LC and LC-MS product launches.

Agilent Technologies has introduced the 1200 Series liquid chromatography system as a successor to its 1100 Series LC. Liquid chromatography represents a $2 billion market and is one of the largest sources of revenue for Agilent's life science and chemical analysis business. Since introducing the 1100 Series instrument in 1995, Agilent has sold more than 400000 modules or 60000 LC systems. To ease the transition to the 1200 Series, the company has made the system reverse-compatible with the 1100 so that customers can combine new and existing modules and continue using existing methods without costly new method development, revalidation or retraining of operators. With more than 60 instrument modules, the system can be configured for all major LC applications, including a rapid-resolution format, preparative scale, standard, narrow, capillary, nanoflow and the company's chip-based liquid chromatography.

Irina Dragan, Evert-Jan Sneekes, and Remco Swart, LC Packings, a Dionex Company

LECO Corporation (St. Joseph, Missouri) recently opened a global support center at its headquarters to serve domestic and international customers. The building will house its service, customer training, and consumables departments. An auditorium, training rooms, cafeteria, and restrooms have been designed exclusively for customers attending training classes. Up-to-date technology has been installed to ensure service and training needs for all customers are met quickly and efficiently.

Joe Macomber, Polymicro Technologies, LLC, Kendrick Walker, Jackson State University, Jackson, Mississippi

Liquid-liquid extraction (LLE) is among the most widely used sample preparation methods. In this month's installment of "Sample Prep Perspectives," Ron Majors discusses newer LLE approaches that offer significant advantages over classical methods. The miniaturization of LLE has resulted in solvent and time savings, improved automation possibilities, and faster sample preparation. The techniques of single-drop microextraction, extraction in levitated droplets, flow injection-, membrane-based-, and solid-supported extractions are reviewed. Often, these techniques use the same immiscible solvent pairs of conventional LLE.

This article describes a software solution for automating the chromatographic method validation process starting from experimental planning, data acquisition and processing, through final report generation in a seamless manner. All experimental planning and calculations are accomplished within the chromatography data software and, thus, are structurally validated, secure, and audit trailed. Highlights of the software are provided, including benefits to the analyst. The analysis of important method validation characteristics such as linearity, accuracy, and precision is automated. These characteristics and their acceptance criteria can be captured in a method template, which adheres to the company's standard operating procedure. This template method can then be used repeatedly by other scientists in the organization, hence, eliminating the need to create a new experimental plan each time a new validation is conducted.

News All the news from January 2006 Opinion Zosimus questions whether we are being charged too much for our columns. Market Trends & Analysis Glenn Cudiamat provides a report on process analytical technology in the biotech and pharmaceutical industry. Evaluating analytical instrumentation using the Golf Score Card tool Timothy R. Baker, Steven H. Hoke II and L.M. Dobson ExTech, HTC-9 and Pittcon focus A useful update on these upcoming shows, together with a preview of some of the exhibitors' latest products. Q&A Ally Lewis from the University of York talks to The Column about his research into the analysis of organic compounds in the atmosphere. Supplies & services

For great advancements in understanding made by intuitive leaps to be successful, they must withstand rational scrutiny.

This postscript to the December 2005 installment "Early Petroleum Chromatographers" outlines the East–West controversy concerning the invention of chromatography.

The authors have developed a method of determining zeranol residues in bovine tissues without using toxic chemicals, organic solvents, and reagents in sample preparation and reversed-phase HPLC separation.

Size exclusion chromatography (SEC) coupled to light-scattering, viscometer and refractive index detectors is a common technique used for the characterization of polymers. In this article the solution conformations of two chimeric IgG3 antibodies were studied using this coupled triple detection technique. Conclusions indicate that the results allow hydrodynamic modeling of the antibody structures.