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Upcoming conferences and events in the chromatography industry.

A new nanospray LC-MS microfluidic chip has been developed that avoids the operational problems that have hindered the broad application of conventional nanocolumn systems. The chip incorporates all of the traditional nanospray LC components on an inert substrate smaller than a credit card.

News All the news from May 2006 Opinion Zosimus reports on the benefits of on-line publishing but also questions why paper is still the dominant form of research publications. Market Trends & Analysis Glenn Cudiamat looks at how rising temperatures are being used to control separation conditions in HPLC and how HPLC media supports cope with this. Meeting focus An overview of the 30th International Symposium on High Performance Liquid Phase Separations and related techniques. Furan in food Colin Crews, Sarah Hasnip and Laurence Castle. USP analysis of tetracylines using reversed-phase polymeric HPLC columns Linda L. Lloyd and Keeley J. Mapp Chips for chromatography Dirk C. Hinz

W. R. Grace & Co. (Columbia, Maryland) recently announced that it will open a technical services laboratory in Shanghai, China, for its Grace Davison Discovery Sciences product group.

Millipore Corporation (Billerica, Massachusetts) recently announced that it has increased its investment in personnel and facilities to support the growth of its business in emerging international markets such as China and India.

Waters Corporation (Milford, Massachusetts) and Bruker BioSciences Corporation (Billerica, Massachusetts) recently entered into a collaboration agreement to provide greater integration and connectivity between Waters? ACQUITY Ultra Performance LC (UPLC) system and Bruker?s mass spectrometry (MS) and nuclear magnetic resonance (NMR) products.

ACD/Labs (Toronto, Canada) announced that it has entered into a reseller's agreement with Applied Biosystems Group (Foster City, California) and MDS SCIEX (Toronto, Ontario).

Water and Bruker annouce collaboration Millipore increases investments in international markets Grace opens center in Shanghai ACD/Labs, Applied Biosystems, and MDS SCIEX sign agreement

The authors define robustness, instroduce a few approaches to designing a robustness study, and discuss data analysis necessary to help ensure successful method implementation and transfer as a part of method validation protocol.

The best parts of the GAMP laboratory system GPG are the life cycle models for both development and implementation of computerized laboratory systems.

Any wine can suffer from that corked wine taint. This spoilage, recognized by a distinct aroma of damp musty leaves and a damp cardboard taste, makes a wine undrinkable.

VICAM, the food safety technology business, headquartered in Watertown, Massachusetts, USA, has been acquired by Waters. The deal also included the associated net assets of VICAM and has proceeded under undisclosed terms.

Column developments in HPLC have benefited protein aqnd peptide separations in a number of ways. More silica based phases and column formats have become available, expanding the use of HPLC for the separation of proteins by different modes of chromatography as well as improving resolution and throughput. Hydrophobic interaction chromatography, immobilized metal affinity chromatography as well as ion Exchange and size exclusion are now practical analytical tools for proteins and peptides. New enrichment columns are benefiting proteomic research.

Chiral separations remain high on the priority list of drug developers. Liquid chromatography and supercritical fluid chromatography continue to vie for dominance in the chiral separation market but might be reaching the state of complementary methodologies. New separation technologies and new advances in current products continue to elevate the state of the art of chiral separations. Automation in both screening for chiral selectivity and preparative purifications has helped make significant gains in productivity in this area.

Although size exclusion chromatography (SEC) is a fairly mature separation technique, improvements are continually made in packing technology. Howard Barth and Greg Saunders review some of the basics of SEC and look at the current status of column technology, including developments for faster and higher resolution size separations.

Ultrahigh-pressure liquid chromatography (UHPLC) is a technique that is experiencing continued growth due to the benefits in separation power and speed of analysis over traditional HPLC. We attempt here to give an overview of some of the advances that have occurred in UHPLC since 2003, from the standpoint of both fundamental research and the introduction of commercially-available technology.

With the advent of column materials that can be used effectively at temperatures well over 100 degrees Celsius, high temperature liquid chromatography (HTLC) separations have gained more attention in the last few years. Advantages of HTLC include fast analysis time, better selectivity, improved column efficiency, and minimization of the use of organic solvents involved in the mobile phase.

The author describes several commercially available novel phases for high performance liquid chromatography separations. Novel phases can provide an alternative and complementary separation for many analyses performed on C8 or C18 columns. Many of the separations discussed in the article could not be accomplished on C8, C18, or even phenyl phases.