All News

This month, John Hinshaw discusses how to make, maintain, and troubleshoot various types of connections used in gas chromatographs.

The robustness/ruggedness of an analytical procedure is a measure of its capacity to remain unaffected by small but deliberate variations in method parameters.

This article describes the use of a 96-well, solvent-resistant filtration plate for total drug analysis in blood plasma.

Liquid chromatography–mass spectrometry (LC–MS) has been increasingly indispensable in most analytical pursuits. Such acceptance would not have occurred without encouraging, early academic efforts and also the efforts of early practitioners who pressed manufacturers to improve and extend electrospray's capabilities. I briefly described the commercialization of LC in its halcyon period of the early 1990s in a 1998 article.¹

Commercialization of the passive sampler is very important because it reflects acceptance by the wider community.

In this installment of "Sample Prep Perspectives," Ron Majors examines modern sample preparation methods for solids that often involve increased temperature and higher pressure to speed up the extraction process.

News from the Chromatography industry.

After you have worked with liquid chromatography (LC) for several years, adjustment of the mobile phase to move peaks around comes almost as second nature. To the newcomer, however, such changes border on magic. One of the rules of thumb that I teach in my short courses is "nothing's magic". This is meant to remind us that chromatography is a very systematic process - study it carefully and you will minimize your surprises. In this month's instalment of "LC Troubleshooting," we'll look at solvent strength and see how we can use it to make predictable changes in the peak movement for reversed-phase LC separations. Hopefully, you will be able to make some practical use out of the principles presented here the next time you need to develop or adjust a method.

LCGC June 2006 BPA

Tosoh Corporation (Montgomeryville, Pennsylvania) announced that as part of strategic initiatives to take advantage of high-growth bioscience-related markets, ?Scientific Instruments Division? will be renamed ?Tosoh Bioscience Division.?

News from the chromatography industry.

Upcoming educational events in the chromatography industry.

Upcoming conferences and events in the chromatography industry.

In this month's issue features two new articles entitled "Accurate Mass Compound Identification with Single-Quadrupole Gas Chromatography-Mass Spectrometry" and "A Chromatographic Screening Method to Identify Agents that Reverse Intrinsic Drug Resistance in Colon Cancer Cells."

Conjugation catalysed by the UDP-glucuronosyltransferase (UGT) superfamily of drug-metabolizing enzymes is an important mechanism of anticancer drug resistance in colon cancer cells. The mechanism manifests itself by a reduction in the intracellular concentrations of the parent drug through increased export of the glucuronide metabolites to the extracellular compartment.

Thermo Electron (Waltham, Massachusetts) announced the acquisition of Fisher Scientific International Inc. (Pittsburgh, Pennsylvania).

PerkinElmer, Inc. (Shelton, Connecticut) announced the acquisition of Spectral Genomics, Inc. (Houston, Texas), a leading company in molecular karyotyping technology used to evaluate chromosomal abnormalities.

Eksigent Technologies, LLC (Dublin, California) announced that David Weber has joined the company as CEO, president, and director.

News All the news from June 2006 Opinion Zosimus looks at the image chromatography has amongst the next generation of separation scientists and tells us why we should forget the past and look to the future. Market Trends & Analysis Glenn Cudiamat updates us on the growing importance of analytical instrumentation to homeland security. Country focus This month we look at some of the latest innovations from Scandinavia. Reversed-phase column selectivity Uwe D. Neue, Bonnie A. Alden, Susan Corman and Joe C. Arsenault. USP analysis of tetracylines using reversed-phase polymeric HPLC columns Linda L. Lloyd and Keeley J. Mapp Supplies & Services Monolith columns for fast, high-resolution HPLC Srinivasa Rao, Jim Thayer and Ilze Birznieks Q&A John Christensen of ESA Biosciences speaks to The Column about its brand new breed of universal HPLC detector based on aerosol discharging.