Application Notes: GC-MS

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The Application Notebook

Column lifetime is a more and more important issue when developing an analytical method for HPLC. Besides sample treatment, column cleaning and storage, operational parameters of the analytical method will have an influence on column lifetime. This question may not always be addressed early enough in the methods development process.

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The Application Notebook

This application note will demonstrate a GC–MS analysis of common polybrominated diphenyl ether (PBDE) congeners. An optimized method will allow the Clarus GC–MS to provide ample separation and high yields of all PBDE congeners. The extended mass range of the Clarus 500 MS and high-mass calibration will produce mass spectra with very high levels of accuracy.

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The Application Notebook

Polybrominated diphenyl ethers (PBDEs) are among the most important and widely used flame retardants. Recent legislation banned certain PBDE congeners.? EU directive 2003/11/EC prohibits the use of Penta-BDE and Octa-BDE for the member states of the European community.? Therefore, analysis of PBDEs have received increased interest as a result of their known toxicity.

The Application Notebook

Protease inhibitors are a class of anti-HIV drugs used in combination therapy to block replication of the HIV virus in a person's blood. It is important to monitor the levels of these drugs in the patient since resistance can develop at low levels and at high levels the drug can exhibit toxic effects.

Application Notes

The Application Notebook

Mini application notes summaries

Application Notes

The Application Notebook

Mini application note summaries...

Application Notes

The Application Notebook

A selection of mini application note write-ups

The Application Notebook

GC column bleed has been postulated to be caused by "backbiting" of the siloxane chain and volatility of noncrosslinked oligimers...

The Application Notebook

The current concern over acrylamide levels in food has unexpectedly brought amino acid analysis to the forefront . . .