Application Notes: GC-MS
Multi-Residue Pesticide Screening Method Using GC–MS
December 2nd 2007Pesticides are widely used by farmers to control pests, weeds and molds that would otherwise decrease crop production. While this has significantly increased worldwide food productions, these same pesticides pose health risks to humans. The restrictions for specific pesticides differ from one country to the next and as world trade increases, the potential threat to other countries' populations increases. For this reason, pesticides and other food related allergens are currently the subjects of increasing scrutiny and regulation.
Thermal Desorption-GC–MS Analysis of Polycyclic Aromatic Hydrocarbons on Fine Particulates in Air
June 1st 2007Polycyclic aromatic hydrocarbons (PAHs) are commonly found throughout the environment in soil, water and adsorbed to fine particulate matter in air. Of the 16 common PAHs, 7 have been classified as animal carcinogens by the International Agency for Research on Cancer (IARC). Resulting from this classification, PAHs are monitored and regulated in the environment.
The Application of GC–MS to the Analysis of Pesticides on Foodstuffs
March 2nd 2007Pesticide contamination of foodstuffs has become a worldwide concern, prompting various levels of regulation and monitoring. Traditionally, pesticides are quantified with gas chromatography (GC) combined with selective detectors (ECD, FID, etc.). Selective GC detectors are great tools to quantify one or two classes at a time. However, screening for a number of different classes of pesticides requires multiple runs utilizing various GC configurations to achieve sufficient chromatographic resolution for unambiguous quantification. Gas chromatography–mass spectrometry (GC–MS) provides positive confirmation of various pesticides in a single analytical run because its superior selectivity allows interference-free quantification even with peak coelution. GC–MS has become a preferred technique for pesticide analysis because of its single-run capability.
Accelerated Buffer System for Amino Acid Analysis
March 2nd 2007The continual increase in sample numbers in busy labs means that it is often difficult for quality control or contract analysis labs to maintain short turnaround times, particularly when instruments are already running at full capacity. To address the need for faster analysis while retaining the quality of separation offered by dedicated amino acid analysers, an improved formulation of sodium citrate based buffers has been developed by Biochrom.
Innovations in Food Analysis — Analysis of Peptides, Additives and Flavours
December 2nd 2006The analysis of peptides and additives using a new HPLC innovative column technology, Pathfinder, was shown. For the analysis of flavours in lemon juice GC–MS with a new MS library, FFNSC, with linear retention indices was used.
Determination of Soft Drink Ingredients
December 2nd 2006Soft drink formulas often include preservatives, artificial sweeteners, flavours or caffeine in their list of ingredients. Using the Acclaim OA column, as many as eight common additives may be determined in a single run. Many of these additives are hydrophilic organic acids for which this column was designed. Notably, benzoate and sorbate, which do not resolve on C18 columns at low pH, are fully separated.
Optimizing Column Lifetime of TSK-GEL Size Exclusion Columns
December 2nd 2006Column lifetime is a more and more important issue when developing an analytical method for HPLC. Besides sample treatment, column cleaning and storage, operational parameters of the analytical method will have an influence on column lifetime. This question may not always be addressed early enough in the methods development process.
Analysis of Polybrominated Diphenyl Ethers Using the Clarus 500 GC–MS
July 2nd 2006This application note will demonstrate a GC–MS analysis of common polybrominated diphenyl ether (PBDE) congeners. An optimized method will allow the Clarus GC–MS to provide ample separation and high yields of all PBDE congeners. The extended mass range of the Clarus 500 MS and high-mass calibration will produce mass spectra with very high levels of accuracy.
Trace Analysis of Brominated Flame Retardants with High Resolution GC–MS
July 2nd 2006Polybrominated diphenyl ethers (PBDEs) are among the most important and widely used flame retardants. Recent legislation banned certain PBDE congeners.? EU directive 2003/11/EC prohibits the use of Penta-BDE and Octa-BDE for the member states of the European community.? Therefore, analysis of PBDEs have received increased interest as a result of their known toxicity.
Tandem GC–MS Analysis of Pesticides in Food Oils by Large Volume Injection with a Back-flush Option
September 2nd 2005As the global sourcing of foodstuffs becomes more common, the number of pesticide analyses performed continues to increase to test these sources for compliance with various regulations. The sheer number of analyses dictates that utilized methods must be reliable, robust and inexpensive.
Determination of Protease Inhibitors Used in the Treatment of HIV
March 2nd 2005Protease inhibitors are a class of anti-HIV drugs used in combination therapy to block replication of the HIV virus in a person's blood. It is important to monitor the levels of these drugs in the patient since resistance can develop at low levels and at high levels the drug can exhibit toxic effects.