Application Notes: Size-Exclusion Chromatography (SEC)
Aggregates and Additives Analysis in Antibody Drugs
This application note demonstrates the separation of IgG monomers and its aggregates, antibody metabolites, and other proteins.
LC–MS Analysis of Low MW Cations under HILIC mode
LC–MS analysis of various low molecular weight cationic compounds were demonstrated using gradient formic acid and acetonitrile eluents.
LC–MS Analysis of Oligonucleotides v2
Oligonucleotides were then analyzed using liquid chromatography with ultraviolet and mass spectrometry with a polymer-based diol column.
Analyzing multiple AAV CQAs with SEC-MALS
This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.
Characterization of Polymer Additives
Combining the benefits of the ACQUITY APC System with the ACQUITY UPLC Refractive Index (RI) Detector and the ACQUITY QDa Mass Detector yields laboratory efficiencies.
Column Screening for UPLC Separation
The selection of appropriate column chemistries to separate eighteen polymer additives are routinely monitored in extractables and leachables (E&L) workflows.
Aiding Lithium Ion Battery Electrolyte Design
A flexible analytical system was used in conjunction with a well-defined informatics workflow to elucidate degradation markers in Li-Ion battery electrolytes.
Two-Dimensional Liquid Chromatography for Polymer Applications
Combining the APC System with WinGPC UniChrom™ software allows researchers to increase the peak capacity of their research.
Accelerating Additive Manufacturing Breakthroughs
Collaborative efforts at Virginia Tech University drive better materials through polymer innovation and additive manufacturing.
SEC-MALS Analysis of Biotherapeutics
How UHP‑SEC‑MALS analysis using a UHPLC compatible multi-angle light scattering detector can be applied to determine absolute molecular weight of recombinant proteins.