Application Notes: Size-Exclusion Chromatography (SEC)
Organic Solvent in Size-Exclusion Chromatography of an Antibody Drug Conjugate Surrogate
This application, using a Biozen dSEC-2 column, demonstrates the effect of organic solvent of an ADC “mimic" on the analysis.
Batch-to-Batch Comparison of Sub-2 µm Diol-Linked Size-Exclusion Columns
NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.
SEC–High Resolution Mass Spectrometry (HRMS) for IdeZ Digested Monoclonal Antibody
SEC–HRMS demonstrated for the analysis of an IdeZ digested mAb for specific identification of any posttranslational modifications specific to the hypervariable region.
Method Optimization for the Analysis of Monoclonal Antibodies by Size-Exclusion Chromatography
This technical report covers how a column packed with small particle material can be used to optimize an analytical method for monoclonal antibody aggregates.
Headspace Sampling for Flavour Profiling of Foods and Beverages
Using high-capacity sorptive extraction with TD–GC–MS analysis for flavour profiling of cider and potato chips, contrasting unflavoured and flavoured-added products
Analysis of Protein Drugs Aggregation Using Size-Exclusion Chromatography
This app note covers aggregate analysis using a Shimadzu Shim-pack™ BioDiol size-exclusion chromatography column with the Nexera XS inert UHPLC.
Conformational Properties of Hyperbranched Hetero-Polysaccharides v2
This note discusses the characterization of conformational properties of hyperbranched macromolecules by combining SEC-MALS with differential viscometry.
Application Note: AAV Application Notebook
AAV characterization and stability screening are achieved with multi-angle light scattering coupled to separation methods and high-throughput dynamic light scattering.
AAV Application Notebook
Learn how AAVs are characterized for critical quality attributes and stability by multi-angle and dynamic light scattering.
Purification and SEC–MALS Analysis of VLP
We investigated the purification and size-exclusion chromatography and light scattering analysis of virus-like particles.