January 2022 | LCGC North America

But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part I: Basic Concepts

January 01, 2022

Column: LC Troubleshooting

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Kinetic plots can help us understand how different combinations of parameters will perform in relation the time needed to acquire a particular column efficiency—and thus resolution.

The QuEChERSER Mega-Method

January 01, 2022

Column: Sample Prep Perspectives

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QuEChERS has been updated to suit modern instrumentation. Now also “efficient and robust,” QuEChERSER is a “mega-method” that covers a wider polarity range.

Is Golay’s Famous Equation for HETP Still Relevant in Capillary Gas Chromatography? Part 1: A Common View of HETP

January 01, 2022

Column: GC Connections

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We are all familiar with Golay’s equation relating to height equivalent to a theoretical plate (HETP) in GC. But do we understand it correctly?

Two-Dimensional Liquid Chromatography (2D-LC): Analysis of Size-Based Heterogeneities in Monoclonal Antibody–Based Biotherapeutic Products

January 01, 2022

Column: Focus on Biopharmaceutical Analysis

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We review different approaches and coupling strategies for analyzing monoclonal antibody aggregates with 2D-LC.

Analyzing Trends of the Cannabis Testing Market

January 01, 2022

Viewpoints

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Given the excitement surrounding the “green rush,” it is worth stepping back to examine the trends and nuances of the cannabis testing environment.

Exploring the Implementation of Compact Chromatographic Instrumentation in Common Analytical Workflows

January 01, 2022

Featured Article

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Compact instrumentation offers important advantages for many workflows, as illustrated by these examples.

Acid-Catalyzed Isomerization of Carbonyls-2,4- dinitrophenylhydrazone in Mainstream Smoke of Heat-Not-Burn Tobacco Product for HPLC Analysis

January 01, 2022

Peer-Reviewed Article

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Errors arising from the DNPH approach commonly used to analyze carbonyl compounds in smoke from heat-not-burn (HNB) tobacco can be avoided by using the approach described in this study.