LCGC North America-03-01-2020

Click the title above to open the LCGC North America March 2020 issue, Volume 38, Number 3, in an interactive PDF format.

Flash chromatography is a purification technique that is designed for rapid separation by using air pressure as opposed to slow and inefficient gravityfed chromatography. It differs from the conventional column technique by using slightly smaller silica gel particles and pressurized gas at 50–200 psi.

How do I know when bioinert liquid chromatography columns, systems, or components are needed for my separations of biomolecules?

Successful GC analysis requires careful control of carrier gas. Here, we explain how to measure and control flow rate, use constant pressure vs. constant flow, and more.

This selection of influential recent papers on chromatographic sample preparation gives us a sense of important developments.

To avoid producing data not fit for purpose, chromatographers need to know how to identify worrying symptoms from HLPC instrument output.

This review addresses recent ideas on the separation mechanism of HILIC, the advantages and disadvantages of the technique, and new applications.

Examination of audit trail entries is a key part of the second-person review. What do regulatory documents say about this topic, and how can we speed up review?

Our interview explores Dan Armstrong’s career of contributions, spanning enantiomeric separations, molecular recognition, ionic liquids, ordered media, mass spectrometry, drug development, environmental research, and food analysis.

Szabolcs Fekete tells us about his work characterizing therapeutic proteins, studying liquid chromatography column technology, and optimizing methods.