An overview of different approaches for the qualitative and quantitative analysis of polysorbates.
Advances in Biopharmaceutical Analysis
In this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.
New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), continue to make progress in both primate and first-in-human trials. As this progress builds, the industry remains accountable for characterizing these molecules to meet the requirements of regulatory authorities.
How is mD-LC–MS changing the way we evaluate HPLC peaks and assess performance?
Davy Guillarme of the Institute of Pharmaceutical Sciences of Western Switzerland and the School of Pharmaceutical Sciences at the University of Geneva (Switzerland) recently spoke with LCGC International about his work analyzing therapeutic oligonucleotides.
Click here to access the Advances in Biopharmaceutical Analysis November/December 2024 Europe PDF.
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