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Why do some peaks front and others don't in the same method?

There are many "minor" variables in GC–MS analysis that can be optimized to improve selectivity or sensitivity. Knowing how to manually optimize the detector settings leads to better quality data.

Some solid–liquid extraction sorbents that have had significant development recently include MIPs, dSPE for QuEChERS, nanomaterials, and mixed-mode and silicone monolith sorbents.

A review of the 7th International Symposium on Packed Column SFC (SFC 2013), which was held in Boston, Massachusetts, from July 10 to 12, 2013.

Click the title above to open the LCGC Europe December 2013 regular issue, Vol 26 No 12, in an interactive PDF format.

Click the title above to open the LCGC North America December 2013 regular issue, Vol 31 No 12, in an interactive PDF format.

Click the title above to open the LCGC North America December 2013 Corporate Capabilities Supplement, Vol 31 No s12, in an interactive PDF format.

Agilent Technologies (California, USA) is to collaborate with the University of Queensland Centre for Clinical Research (Brisbane, Australia) to further understanding of the genomic differences governing oral cancer. According to the National Center for Biotechnology Information, oral cancer is the sixth most prevalent cancer worldwide.

Agilent Technologies (California, USA) is to collaborate with the University of Queensland Centre for Clinical Research (Brisbane, Australia) to further understanding of the genomic differences governing oral cancer. According to the National Center for Biotechnology Information, oral cancer is the sixth most prevalent cancer worldwide.

PerkinElmer (Massachusetts, USA) has appointed Jon DiVincenzo as President, Environmental Health and Senior Vice President. DiVincenzo will take responsibility for the company?s environmental health business, which focuses on ensuring safer food and a cleaner environment.

Pumping Technologies

Kromasil UHPLC columns with 1.8 ?m spherical silica particles are the latest addition to the Classic Kromasil product line. With the highest efficiency, they will give you the best resolution with minimized turnaround time and laboratory costs.

LCGC North America Edit Calendar

The U.S. Pharmacopeial Convention (USP) (Maryland, USA) has announced that it will join the ?Fight the Fakes? campaign to raise awareness of counterfeit and substandard medicines.

This article describes analyte adsorption in vials with reduced surface activity compared to those made from standard borosilicate glass.

Scientists from San Pablo CEU University (Madrid, Spain) have developed a non-targeted global fingerprinting approach for lung tissue samples by performing three analytical methods ? liquid chromatography coupled to mass spectrometry (LC–MS), gas chromatography coupled to MS (GC?MS), and capillary electrophoresis coupled to MS (CE–MS). Published in the journal Analytical Chemistry, the study details the development and validation of the multi-platform approach using 20 mg of lung tissue.1

Donna Nelson of the University of Oklahoma, USA, and scientific advisor to the hit television show Breaking Bad spoke to The Column about her research in academia, as well as her role on the show.

Scientists from the Duke Medical Center (North Carolina, USA) and the Bascom Palmer Eye Institute at the University of Miami (Florida, USA) have performed liquid chromatography coupled to mass spectrometry (LC?MS) to identify a new diagnostic marker of Retinitis pigmentosa (RP) in patient urine samples.1 RP is a disease of the eye that causes retina degradation and can result in blindness. Often inherited, it has multiple contributing genetic mutations and there is no treatment available.

The Gulf of Mexico Research Initiative (GoMRI) has announced plans to invest up to $105 million between 2015 and 2017 to support research consortia investigating the effect and impacts of hydrocarbon release into the environment. The funding will be awarded to four or more institutions over two years, under the program known as RFP?IV. GoMRI report that each team will be funded between $1 million and $7.5 million per year.

Potentially dangerous levels of the methamphetamine analogue, N, ??diethyl?phenylethylamine (N, ? -DEPEA), have been detected in a widely available dietary supplement using ultrahigh-pressure liquid chromatography coupled to mass spectrometry (UHPLC–MS). The supplement, Craze, can be bought in the USA and from on-line retailers. The findings have been published in the journal Drug Testing and Analysis by a team of scientists from Harvard Medical School (Massachusetts, USA), NSF International (Missouri, USA), and the National Institute for Public Health and the Environment Health Protection Center (Bilthoven, The Netherlands).1

Click here to view the complete E-Separation Solutions newsletter from November 21, 2013.

The Gulf of Mexico Research Initiative (GoMRI) has announced plans to invest up to $105 million between 2015 and 2017 to support research consortia investigating the effect and impacts of hydrocarbon release into the environment. The funding will be awarded to four or more institutions over two years, under the program known as RFP?IV. GoMRI report that each team will be funded between $1 million and $7.5 million per year.

Based on Wyatt Technology?s legacy of multi-angle light scattering (MALS) detectors, the DAWN HELEOS-II is the MALS detector with the greatest sensitivity for absolute molecular weight and size determinations of polymers and biopolymers in solution. The DAWN may be connected in series to any chromatographic system in order to determine absolute molar masses without the use of reference standards or column calibration.

Click here to view the full European E-newsletter from 21 November.

No, this isn't a new detective novel, in fact its two concepts which were "coined" by my good friend John Hinshaw during a recent CHROMacademy webcast which we presented together on sample introduction for capillary GC.

LCGC North America proudly presents the 7th Annual Emerging Leader in Chromatography award. The Emerging Leader award recognizes the achievements and aspirations of a talented young separation scientist who has made strides early in his or her career toward the advancement of chromatographic techniques and applications. The winner will be featured on the cover of a 2014 issue of LCGC and in a interview that will be featured in our electronic newsletter, e-Separations Solutions and on the LCGC website.

Click here to view the full European E-newsletter from 14 November.