Scientists from Bristol-Myers Squibb Company have developed a novel approach for the simultaneous quantitation of neutralizing antibodies, residual drug, and human Immunoglobulin G (IgG) in immunogenicity assay development using liquid chromatography?tandem mass spectrometry (LC–MS–MS). This work published in Analytical Chemistry presents a new approach that aids the refinement of therapeutic protein neutralizing antibody assays in drug development.
E-Separation Solutions
Click here to view the complete E-Separation Solutions newsletter from April 3, 2014.
LCGC Europe eNews
Analytica 2014 Thursday Afternoon Sessions
LCGC Europe eNews
Analytica 2014 Wednesday Afternoon Sessions
Special Issues
Chromatography has taken a prominent place in the characterization and analysis of protein therapeutic drugs and today it plays a critical role in the biotechnology laboratory.
LCGC North America
Gerard Rozing has been announced as the winner of the second annual Uwe D. Neue Award in Separation Science.
Special Issues
An examination of the development of new types of columns based on different particle types, sizes, and other physical characteristics and how they can improve the speed and efficiency of HPLC used to support more expansive and complicated analyses
LCE December 2013 BPA
LCGC NA December 2013 BPA
LCGC North America
The winners of LCGC's seventh annual awards are highlighted.
LCGC North America
New product introductions in the areas of HPLC columns for reversed-phase LC, HILIC, ion-exchange and ion chromatography, SEC, and specialty columns for specific types of analyses are covered.
Special Issues
A brief introduction to the articles presented in this supplement
LCGC North America
Why do core–shell particles provide an increase in efficiency?
Special Issues
Size-exclusion chromatography is an important technique in biopharmaceutical characterization. This article discusses its use for soluble aggregation analysis and quantitation.
LCGC Europe
Some attributes of large molecules make them behave differently from small molecules in reversed-phase separations.
LCGC Europe
The variation in selectivity of aromatic hydrocarbons with bisubstituted polar groups is investigated in systems consisting of C18 stationary phase and ternary eluents. The solutions of the ternary eluents were obtained by mixing binary solvents (organic modifier + water) of similar eluent strength. Acetonitrile, methanol and tetrahydrofuran were the organic modifiers applied. The influence of the organic solvent type and its concentration in the ternary mobile phase on retention and selectivity of the solutes is discussed. An approach previously presented by our group was adapted to explain the selectivity changes.
LCGC Europe
Part 1 of our annual report on new products introduced at Pittcon. This month, columns are highlighted, covering HPLC/UHPLC columns, packings, and related products.
Analytica 2014 Tuesday Afternoon Sessions
LCGC Europe
Click the title above to open the LCGC Europe April 2014 regular issue, Vol 27 No 4, in an interactive PDF format.
Special Issues
Click the title above to open the LCGC North America April 2014 Recent Developments in LC Column Technology Supplement, Vol 32 No s4, in an interactive PDF format.
LCGC North America
Click the title above to open the LCGC North America April 2014 regular issue, Vol 32 No 4, in an interactive PDF format.
Nick Snow of Seton Hall University studied the presence of drugs of abuse in various complex matrices to detect trace quantities of drugs of abuse using GCxGC–TOF–MS as his method of choice.
LCGC Europe eNews
Thermo Fisher Scientific (California, USA) and Harvard Medical School (Boston, USA) have teamed up to establish the Thermo Fisher Scientific Center for Multiplexed Proteomics at Harvard Medical School. The facility has been set up for the development of new methods for protein quantitation, as well as the development of training courses to make expertise available to the wider community.
LCGC Europe eNews
The ACS Women Chemists Committee (WCC) has awarded a 2014 WCC Rising Star Award to Katherine Ayers, Director of Research for Proton OnSite (Connecticut, USA). The award recognizes exceptional early to mid-career women chemists from across all areas of chemistry on a national level.
LCGC Europe eNews
The latest newsletter from March 27.
