A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
At the Recent Advances in Food Analysis (RAFA) conference in 2024, LCGC International sat down with Stefan van Leuwen of Wageningen Food Safety Research to discuss his research, which addresses emerging challenges in circular food production, focusing on the risks posed by pollutants when waste and by-products are repurposed in food systems.
At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
Differences in serum metabolites of sheep infected with Echinococcus granulosus were analyzed using ultrahigh-performance liquid chromatography (UHPLC) separation with tandem mass spectrometry (MS/MS) detection, providing a basis for the early diagnosis and pathogenetic study of cystic echinococcosis (CE) in intermediate hosts at the metabolomics level.
Shimadzu Corporation is celebrating 150 years since it was founded with a dedicated website and a collaboratively designed logo.
In forensic science, scientific testimony is routinely presented in court to juries who may have limited or no scientific background, putting law enforcement and defense personnel in the position of having to make rapid decisions in short timeframes based on findings of which they are not specialists. Katelynn Perrault Uptmor, Assistant Professor of Chemistry at William & Mary (Williamsburg, Virginia) believes that the introduction of new technologies into the framework of routine forensic analysis must therefore bridge the gap between introduction of new and novel analytical science and the communication of that science to a court of law, and that analytical chemistry research must be mindful of the need to fill this gap in promoting new technologies.
An overview of different approaches for the qualitative and quantitative analysis of polysorbates.
Researchers employed a gas chromatography-mass spectrometry (GC–MS)-based metabolomic approach combined with sophisticated statistical methods to identify metabolic biomarkers in coronary heart disease (CHD), hypertension-comorbid CHD, depression-comorbid CHD, and type 2 diabetes mellitus (T2DM)-comorbid CHD to provide an objective diagnostic method and help identify metabolomic signatures to better identify risk groups early, as well as improve understanding of pathophysiologic pathways.
How is mD-LC –MS changing the way we evaluate HPLC peaks and assess performance?
Davy Guillarme of the Institute of Pharmaceutical Sciences of Western Switzerland and the School of Pharmaceutical Sciences at the University of Geneva (Switzerland) recently spoke with LCGC International about his work analyzing therapeutic oligonucleotides.
In 2024, we launched a content series, covered major conferences, presented prestigious awards, and continued our monthly Analytically Speaking podcasts. Below, you'll find a selection of the most popular content from LCGC International over the past year.
Schmitz's lab will now integrate the company’s structures for lossless ion manipulation (SLIM) technology into their research as part of this new partnership.
Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
A recent study examines the specific traits of the intestinal microbiota and metabolites in Bactrian camels. The results of profiling 36 intestinal mucosal samples from six Bactrian camels using liquid chromatography with tandem mass spectrometry (LC-MS/MS) provides valuable data for understanding the relationship between regional intestinal immunity and the general health and disease of the host.
A recent study used gas chromatography-mass spectrometry (GC-MS) to evaluate the potential of the foliar application of C. vulgaris extract to improve crop yield, chemical composition, and antioxidant and antibacterial activities of the essential oil of spearmint.
Researchers from the University of Copenhagen (Denmark) have developed a broad screening strategy using evaporation enrichment and liquid chromatography high-resolution mass spectrometry (LC–HRMS) to evaluate migration of non-volatile chemicals from various reusable plastic bottles. LCGC International spoke to Selina Tisler, corresponding author of a paper resulting from the research, about this strategy.
A compilation of Q&A interviews on food analysis is presented here.
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to enhance dicarboxylic acid (DCA) detection and quantification in different biological matrices has been developed and optimized.
As part of our “From Lab to Table: How Chromatography is Shaping Food Analysis” content series, we present a compilation of highlights from the Recent Advances in Food Analysis (RAFA) conference.
Research conducted by the Chinese Academy of Tropical Agricultural Sciences (Wenchang, China) investigated the changes in flavonoid metabolite profiles in coconut water from two varieties, Wenye No.5 (W5) and Hainan local coconut (CK), across six developmental stages, utilizing liquid chromatography-tandem mass spectrometry (LC–MS/MS) in their work. Their findings have repercussions in yielding coconut-based products offering superior nutritional and functional properties.
Citrinin, a hepato-nephrotoxic mycotoxin produced by fungal species, plays a crucial role in the fermentation of red rice to produce red yeast rice-based food supplements, which represent the primary source of human exposure to this contaminant. A recent study conducted by the University of Valencia and the Public Health Laboratory of Valencia (Spain) developed and validated a simple and sensitive analytical method for the citrinin determination in these products.
To determine sample patterns and identify possible markers of quality, variety, or origin to deal with authentication or fraud detection issues, researchers from the University of Barcelona’s Department of Chemical Engineering and Analytical Chemistry characterized dark chocolate samples according to geographical origin, cocoa variety, and cocoa content. Filtered extracts were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV) and spectrophotometric methods to establish individual phenolics and overall indexes of antioxidant and flavonoid content.
LCGC International sat down with Giorgia Purcaro of the University of Liege to discuss the impact that solid-phase microextraction (SPME) and comprehensive multidimensional gas chromatography (GC×GC) is having on food analysis.
A recent study conducted at the Department of Biotechnology of Thapar Institute of Engineering & Technology (Punjab, India) examined the isolation and characterization of catechin-producing endophytic fungi isolated from tea leaves, their chemical characterization, and associated bioactivities. LCGC International spoke to Priyankar Dey of the Thapar Institute of Engineering & Technology about the work done by his group, and the paper that resulted from it.
In this article, we review some key considerations for chromatographic technique selection and method development across the full drug process—from early-stage active pharmaceutical ingredient (API) synthesis to routine commercial release activities.
In this column, we discuss the label-free and stable isotope labeling proteomics approaches that help in biomarker discovery. We also discuss the different enrichment techniques, such as stable isotope labeling by amino acid in cell culture (SILAC), isobaric tags for relative and absolute quantitation (iTRAQ), and tandem mass tags (TMT, that help in measuring low-abundance protein biomarkers.
LCGC International spoke to Silvia Valverde and Ana María Ares of this group about their research and the resulting article.
A high performance liquid chromatography–ultraviolet (HPLC–UV)-based method was recently developed for the quantification of selpercatinib in human plasma, an advance that may lead to the reduction of adverse events as well as an optimization of efficacy.
Following the HPLC 2024 Conference in Denver, Colorado, LCGC International spoke with Anne Marie Smith of ACD/Labs about the new ICH Q14 guidelines and how they impact analytical scientists and their work.
