All News

In this installment of "LC Troubleshooting," Dwight Stoll discusses several essential principles related to when and why buffers are important, as well as practical factors, such as commonly used buffering agents, that are recommended for use with different types of detectors.

Researchers measured bovine tooth enamel samples with colorimetry, high-performance liquid chromatography (HPLC), and ultraviolet-visible (UV-Vis) spectrophotometry to develop a comprehensive understanding of coffee-induced tooth discoloration by examining the individual and combined effects of CGA and pigments and determining how their concentrations are affected by coffee roast level.

Separation and Characterization of Macromolecules 11 (SCM-11) will take place from 22–24 January 2025 in Amsterdam, The Netherlands.

LCGC International spoke with Jim Gearing, Associate Vice President of Marketing, Agilent Gas Phase Separations Division; Massimo Santoro, Group Business Development Director at Markes International; Ed Connor, GC Product Manager at Peak Scientific; and Bruce Richter, Vice President of Research & Development at Restek Corporation.

LCGC International spoke to Phil Marriott and Humberto Bizzo about a recent paper they published identifying the incorrect use of retention indices in gas chromatography and how this problem can be rectified in practice.

A recent study investigating the association between dietary polyunsaturated fatty acid (PUFA) intake and estradiol levels in women in the United States utilized isotope dilution liquid chromatography–tandem mass spectrometry to measure serum estradiol levels.

Using a solid phase microextraction gas chromatography-mass spectrometry (SPME GC-MS)-based metabolomics approach, a recent study by the School of Life Sciences and Technology at Institut Teknologi Bandung (Indonesia) investigated the impact of environmental factors (including temperature, rainfall, and altitude) on volatile metabolite profiles of Robusta green coffee beans from West Java.

LCGC International sat down with Christopher Kozak, a professor at Memorial University to speak about his recent research using MALDI-TOF analysis to identify unknown blobs in Newfoundland, Canada’s Placentia Bay.

Researchers showed that a 12-week aerobic exercise regimen reduced circulating branched-chain amino acid levels in obese mice while attenuating insulin resistance.

Researchers used high performance liquid chromatography and untargeted metabolomics by Fourier-transform ion cyclotron resonance-mass spectrometry to highlight the critical role of root exudates in drought tolerance.

In this edition of “Inside the Laboratory,” Jillian Goldfarb of Cornell University discusses her laboratory’s work with using gas chromatography–mass spectrometry (GC–MS) to characterize compounds present in biofuels.

Click here to access the Advances in Biopharmaceutical Analysis November/December 2024 Europe PDF.

A recent study identified and quantified anthocyanin (which are known for their antioxidative properties and potential effectiveness against depression) in blueberries, blackberries, black mulberries, and cranberries using ultra high-pressure liquid chromatography (UHPLC) followed by in vivo evaluation of their antidepressant-like activities.

In this edition of “Inside the Laboratory,” Andrew Zydney of Pennsylvania State University discusses his laboratory’s work with using high performance liquid chromatography (HPLC) to analyze biopharmaceutical products before and after membrane separation processes.

A recent study measured stress and reproductive hormones in three stocks of free-ranging bottlenose dolphins inhabiting different natural salinities across the Gulf of Mexico, with hormones extracted from the blubber of 82 remotely biopsied dolphins and quantified using ultrahigh-pressure liquid chromatography (UHPLC) coupled with orbital ion trap fusion mass spectrometry.

“Strange blobs” that started washing up on Newfoundland’s shores months ago may have been identified through a Canadian chemist’s investigation using mass spectrometry (MS).

Scientists from the Massachusetts Institute of Technology, the University of Washington, and other leading institutions took the stage at the Eastern Analytical Symposium to accept awards and share insights into their research.

After collecting dried blood spots from preterm infants with gestational age (GA) of less than 32 weeks within 24 hours after birth, researchers used liquid chromatography-tandem mass spectrometry (LC–MS/MS) to perform targeted measurements of metabolites to identify differential metabolites in preterm infants with bronchopulmonary dysplasia and uncovering circulating biomarkers for the early prediction of this chronic lung disease.

In this edition of “Inside the Laboratory,” Susan Richardson of the University of South Carolina discusses her laboratory’s work with using electron ionization and chemical ionization with gas chromatography–mass spectrometry (GC–MS) to detect DBPs in complex environmental matrices, and how her work advances environmental analysis.

Aiming to develop a comprehensive strategy for evaluating the chemical migration from various reusable plastic bottles, researchers from the University of Copenhagen utilized vacuum evaporation concentration (VEC) enrichment combined with liquid chromatography (LC) high resolution mass spectrometry (HRMS) analysis to investigate a wide range of materials from different manufacturers to identify those with higher and lower chemical migration rates.

A recent study evaluated the potential of fruit by-products from acerola, guava, and tamarind’s potential in producing fermented beverages, with their acid profiles determined by high performance liquid chromatography (HPLC).

A recent study set out to assess the significance of geographical and varietal factors in the content of alkaloids, phenolic compounds, and the antioxidant capacity of chocolate samples. Filtered extracts were analyzed by reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet (UV) and spectrophotometric methods to determine individual phenolics and overall indexes of antioxidant and flavonoid content.

The pivotal role of analytical chemistry in the medico-legal and forensic applications is explored in this article.

Liquid chromatography and tandem mass spectrometry (LC–MS/MS) was used to show that repeated stress can cause delayed but sustained changes in blood plasma proteins associated with water conservation, immune responses, fat metabolism, insulin sensitivity, iron recycling, and hormone transport in elephant seals. Some of these changes may be novel markers of recent and chronic stress exposure in marine mammals.

Click here to access the Hot Topics in Mass Spectrometry October 2024 North America PDF.

Click here to access the Hot Topics in Mass Spectroscopy October 2024 Europe PDF.

LCGC International spoke to Heather Barkholtz and Maia Bates of the University of Wisconsin-Madison about their recent evaluation of a broad screening technique for high-priority drugs of abuse in whole blood.

A recent study investigated the protein composition and baking quality of 14 German common wheat landraces, with 6 modern varieties serving as a control group. The protein composition was determined using modified Osborne fractionation and reversed-phase high-performance liquid chromatography (RP-HPLC).