Application Notes: Biological, Medical, and Clinical

LC–MS–MS methods for the unambiguous identification and quantification of pesticides in complex matrix samples are well known and widely used. Triple quadrupole systems have proven useful for this task because of their high specificity in MS–MS mode and their low detection limits. However, working in targetted MS–MS mode prevents the detection of other compounds.

The continual increase in sample numbers in busy labs means that it is often difficult for quality control or contract analysis labs to maintain short turnaround times, particularly when instruments are already running at full capacity. To address the need for faster analysis while retaining the quality of separation offered by dedicated amino acid analysers, an improved formulation of sodium citrate based buffers has been developed by Biochrom.

Daniel Krug, Gabriela Zurek, Birgit Schneider, Carsten Bässmann and Rolf Müller, Bruker Daltonik

(3R, 3’R)-zeaxanthin is one of several dietary carotenoids found in human ocular tissue. Research has shown that concentrations of zeaxanthin, as well as other carotenoids, are significantly lower than normal in the macula of persons diagnosed with neovascular age-related macular degeneration (AMD)...

Protease inhibitors are a class of anti-HIV drugs used in combination therapy to block replication of the HIV virus in a person's blood. It is important to monitor the levels of these drugs in the patient since resistance can develop at low levels and at high levels the drug can exhibit toxic effects.

VENTURE A affinity columns utilize ICEtechTM surface passivation technology...

Polymeric monolithic stationary phases offer an alternative to the classical microparticulate sorbents...

State-of-the art two-dimensional (2-D) nano LC coupled to mass spectrometry (MS) provides a powerful analytical tool...

Size exclusion chromatography (SEC) coupled with mass spectrometry was used to study . . .