Application Notes: Biological, Medical, and Clinical

Studies of adenosine monophosphate (AMP) and phosphorylated sugar in rat blood have become increasingly important in toxicology and insulin investigation. HPLC is typically the ideal method for this study. Shodex VT-50 2D would be the ultimate column due to its cAMP and AMP capabilities.

This application note describes the development of an analytical method for the sensitive and accurate determination of free and total thyroid hormones in serum and plasma using a mixed-mode SPE extraction procedure and UHPLC–MS-MS analysis.

This application utilizes the original, non-buffered QuEChERS (acronym for quick, easy, cheap, effective, rugged, and safe) technique to quantify anabolic steroids in human whole blood

Polar neurotransmitters are difficult to retain using ODS columns. In this work we show two different methods to retain these polar analytes on the multi-mode Scherzo SS-C18 column. The versatility in retention characteristics with simple changes in mobile phase is highlighted.

Membrane proteins - together with lipids - make up biological membranes that are essential for life. In order to understand the role of membrane proteins in assisting membranes to carry out many different functions, it is of great importance to understand the structure of those proteins.

Most proteins, particularly soluble and membrane-bound proteins expressed in the endoplasmic reticulum, are glycosylated. The extent and result of glycosylation varies.

Organochlorine (OC) pesticides are hydrocarbons with multiple chlorine substitutions primarily used as insecticides. OC pesticides do not break down easily as the chlorine-carbon bonds are very strong.

The physical properties and behavior of polymers depends strongly on the properties of the polymer molecules themselves

The Intrada Amino Acid column has been shown to be a viable solution for the analysis of amino acids by LC–MS without derivatization.

Gel filtration chromatography (GFC) is a powerful analytical tool in the separation of antibodies. Traditionally, GFC columns with a dimension of 7.8 mm i.d. × 30 cm are used for analytical purposes.

Tosoh Bioscience LLC

Agilent Technologies Inc.

ZirChrom Separations, Inc.

Wyatt Technology Corporation

Bruker Daltonics

Wyatt Technology Corporation

Bruker Daltonics Inc.

LECO Corporation

Malvern Instruments Ltd.

Tosoh Bioscience LLC