Application Notes

Articles

SPME-UHPLC/MS/MS offers an efficient alternative for the analysis of veterinary drug residues in animal tissue as compared to traditional sampling procedures.




Analysis of Veterinary Drugs in Chicken by SPME-UHPLC/MS/MS

The Quasar biphenyl HPLC phase offers high efficiency separation and excellent peak shape of the synthetic antibiotic, ciprofloxacin. 



HPLC Analysis of the Synthetic Antibiotic Ciprofloxacin

This application note describes using a Quasar biphenyl LC column in analyzing several cephalosporins, a mixture of first and second generation β-lactam antibiotics.


Analyzing Cephalosporins Using a Quasar Biphenyl LC Column

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Method Validation for Atrazine Analysis

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

Analysis of Challenging Polar Contaminants in Water 

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

Analysis of PPCPs in Drinking Water 

IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) for better characterization of the Fc fragment.

Analysis of IgeS Digested Monoclonal Antibody Fragments

Selectivity of two high-pH stable Agilent InfinityLab Poroshell 120 C18 columns is compared with pesticides using a pH 10 formate buffer and acetonitrile gradient.

Method Development of C18 Columns and High pH

This application combines cysteine proteases IgdE and IdeS, to observe conserved and hypervariable regions of the antibody, as well as identification of other variants.

Tandem Digestion of Monoclonal Antibodies Using Novel Cysteine Proteases

IgdE allows for better characterization of the antibody and yields an intact Fc and an intact Fab fragment that can be further isolated and characterized.

Application Notes: LC