Application Notes: LC

Accurate detection of halo acetic acids is paramount for the prevention of over oxidation, while still managing enough water sanitation to eliminate water-borne pathogens.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

This application introduces the automated analysis of fluorescent diastereomers of the proteinogenic D/L-amino acids using derivatizing reagents with chiral structures.

This goal of this note is identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC–MS in a top-down experiment.

The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.

In this study, we confirm the high selectivity of CPC and its capability to purify a set of key compounds and enrich several minor cannabinoids in a single step.

Exploring isotopes in petrochemical materials can reveal information on original source materials, and maturation and biodegradation processes on different time scales.

Detect aflatoxins B1, B2, G1, and G2 and sterigmatocystin in complex (and simple) sample matrices using a streamlined approach with LC.

Antiretrovirals have come back to the forefront of separation science at this moment in time, as they have found use in the fight against SARS-CoV-2.

Erythromycin analysis in creams, lotions, etc., based on HPAEC-PAD using the ALEXYS Antibiotics Analyzer according to the official 2018 USP 41—NF36 monograph.

SMX and TMP are the active ingredients of Co-trimoxazole or Bactrim. They can be analyzed easily and inexpensively using HPLC with pulsed amperometric detection.

The ALEXYS HPAEC-PAD Analyzer is used for the analysis of both antibiotics, in accordance with the USP 38 monographs.

A HPAEC-PAD method is presented for the sensitive analysis of mono-, di-, and trisaccharides in plant tissue extracts and root exudates..

This application note demonstrates a fast, selective, and sensitive method for the analysis of lactose and isomers based on HPAEC with Pulsed Amperometric Detection.

A HPAEC-PAD method with a four-step potential waveform is applied for the analysis of Erythritol, Xylitol, Sorbitol, Mannitol, and Maltitol, resulting in excellent reproducibility.

The ALEXYS Antibiotics Analyzer is used for routine assay and impurity analysis of Azithromycin in various formulations according USP 41 monographs.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

This article introduces a comprehensive fractionation for both UV absorbing and non-UV absorbing compounds using a newly designed PDA-ELSD triggered preparative LC.  

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

The Epic C18 column provides efficient and repeatable separations for finasteride, meeting all suitability requirements in the USP monograph.

The superior base deactivation and high-density bonding technology of the Epic C18 phase yields excellent peak shape in betamethasone analyses.

This application brief describes the use of an Epic C18 column for the analysis of acetaminophen, aspirin, and caffeine yielding rapid and reproducible results.

This application brief describes the use of an EpicTM C18 to analyze three ginsenosides using a method based on the Chinese Pharmacopeia.

Learn how to use flash chromatography and prep HPLC for protein purification, parameters that improve resolution, and how to select the stationary phase and solvent.

This note demonstrates the determination of PAH4 inedible oils with automated sample enrichment and matrix elimination (online solid-phase extraction - online SPE).

This application demonstrates the efficiency, throughput, and reliability of a dual-injection system for finished pharmaceutical products and in-process APIs.

Cannabinoids have similar molecular structures, making purification a challenging step. Learn how centrifugal partition chromatography can simplify this process.

Synthetically derived food and beverage dye analysis to meet regulatory requirements aimed at reducing the risk of allergies, cancers, and attention deficits.