Agilent Technologies, Inc.

A single quadrupole GC–MS instrument configured with the Agilent HydroInert source meets US EPA method 8270 calibration criteria with H2 carrier gas.

This application demonstrates low detection limit capabilities of the Agilent 7000E triple quadrupole GC–MS, meeting EPA 8270 requirements when using H2 carrier gas.

This application note describes two approaches for achieving robust, multiresidue pesticide analysis in 10 minutes by GC/MS/MS, while maintaining sufficient chromatographic resolution for the analysis of over 200 pesticides in spinach; a challenging high chlorophyll, fresh matrix.

Gas chromatography/mass spectrometry (GC/MS) is integral to the analysis of semivolatile organic compounds (SVOCs) in environmental matrices. Recent pressure on the helium (He) supply has required organizations to actively investigate hydrogen (H2 ) carrier gas, but most GC/MS analyses have reduced sensitivity and hydrogenation or dechlorination in the sources. The Agilent HydroInert source retains the ability to analyze a wide calibration range (0.1 to 100 µg/mL) and meet the U.S. Environmental Protection Agency (EPA) method 8270 calibration criteria when using H2 carrier gas.

This poster demonstrates an MRM-based multiple-residue LC/MS method for forensic drug quantitation using the new optimizer software on the new Agilent 6475 LC/TQ resulting in several improvements on the new acquisition software

Tuesday, June 7th, 2022 at 2pm EDT | 11am PDT | 7pm BST | 8pm CEST Join Benjamin Southwell and Derek Wright from Lake Superior State University to learn some strategies for developing a highly qualified cannabis testing workforce and providing on going professional development to keep pace with the rapidly evolving cannabis industry.

Wednesday, May 25, 2022 at 11am EDT|8am PDT|5pm CEST|4pm BST In the last few years, the issuance of the ISO 10993-18:2020 medical device guidance and several high-profile publications and round robin studies have resulted in the FDA increasing scrutiny of E&L analyses for both drugs and devices. Join our panel of industry experts to discuss these changes and to learn the direction E&L studies may take in the future.

Automated MHC-I is associated peptide enrichment using the Agilent AssayMAP Bravo platform with large-capacity Protein A cartridges for immunopeptidomics analysis.

The AssayMAP Bravo was used to purify, digest, and clean up antibodies from 96 cell culture supernatants with high reproducibility and minimal labor prior to LC–MS.

Intact and subunit antibody mass determination was streamlined using automated purification and enzymatic cleavage and deglycosylation of immobilized antibodies.

Automated sample prep and LC–MS peptide mapping approach to characterize and quantify multiple monoclonal antibody (mAb) critical quality attributes (CQAs)

Automated phosphopeptide enrichment from cell lysates with Fe(III)-NTA enables the identification of thousands phosphopepides with high reproducibly and selectivity.

Automated phosphopeptide enrichment and ion mobility mass spectrometry (IMS-MS) enables detailed analysis of structural effects of site-specific phosphorylation.

Automated Antibody Drug Conjugate (ADC) purification and deglycosylation increases reproducibility and simplifies drug-to-antibody ratio (DAR) determination

Improved host cell protein analysis using highly reproducible and scalable automated sample digestion and fractionation ahead of LC–MS coupled with iterative MS–MS

This application note presents a reversed-phase LC method capable of separating all relevant reduction-induced LMW species of the NISTmAb.