Agilent Technologies, Inc.

Articles by Agilent Technologies, Inc.

As analytical methods like high-performance liquid chromatography (HPLC) evolve, it becomes increasingly complex for labs to balance performance, price, and support. This infographic, based on independent LCGC International surveys commissioned by Agilent Technologies, reveals evolving end-user preferences, top performance drivers, and brand rankings in reliability and cost-efficiency.

Forward-thinking labs can make smarter, more cost-effective decisions when investing in quality analytical liquid chromatography (LC) systems. This eBook, based on the findings from biannual surveys conducted by LCGC International in partnership with Agilent Technologies, uncovers the hidden costs behind instruments and shows how reliability, expert customer support, and long-term value can drive operational excellence. Ultimately, cutting-edge innovations, including ultra-high performance liquid chromatography (UHPLC), are redefining performance, speed, and scientific potential in the modern LC lab.

As PFAS contamination spreads across the environment, advanced screening and characterization techniques are crucial for detection and risk assessment. This e-book explores cutting-edge analytical methods for identifying PFAS in environmental and biological samples.

Agilent and Scitara are collaborating not only to increase the efficiency of laboratory processes, but to enable customers to leverage the value of the data for various stakeholders. This paper will present an ecosystem designed to support enterprises in accelerating data workflows and improving data availability for researchers, lab analysts, and data scientists.

Oligonucleotides—therapeutic agents for difficult-to-treat diseases—rely on precise molecular weight confirmation to ensure quality during development. Experts from Agilent Technologies explore the challenges of liquid chromatography-mass spectrometry (LC/MS) analysis in oligonucleotide synthesis, as well as strategies for accurate deconvolution, method development, and optimal equipment selection.

Top-down fragmentation enables rapid characterization of phosphorylated proteins without extensive sample preparation and digestion. In this study, electron capture dissociation (ECD) was used to fragment proteoforms of the cell death-related protein, Bcl-xL. Using these methods, 85–90% sequence coverage was achieved for Bcl-xL proteoforms, allowing for effective localization of phosphorylation within minutes.

Enhanced antibody analysis using electron capture dissociation (ECD) allows for precise glycan localization in low-abundance glycopeptides. This study compares the fragmentation of trastuzumab tryptic digests using ECD and collision-induced dissociation (CID). While CID generates abundant glycan HexNAc ions at 204 m/z, ECD preserves the labile glycan group, enabling accurate site localization.