John Chasse

Using chromatography-based analysis, researchers demonstrate how complementary alcohol biomarkers can help distinguish between recent binge drinking and repeated alcohol consumption in forensic driving investigations.

Researchers developed and validated a LC–MS/MS method for the detection of antibacterial, antifungal, and antiparasitic residues in legume-based alternative protein products. LCGC International spoke to Awanwee Petchkongkaew and Chanita Boonkanon, corresponding and lead authors, respectively, of the paper outlining this work.

Supercritical CO₂ extraction of limoncello-derived lemon peels, followed by gas chromatography-mass spectrometry (GC–MS) analysis, revealed monoterpene-rich chemical profiles with antioxidant, antimicrobial, and skin-beneficial potential, supporting their value as sustainable cosmetic ingredients.

HIC-MS, ADC characterization, career insights, and aroma and protein detection research highlight this week’s website offerings.

Using liquid chromatography–mass spectrometry (LC–MS), researchers compared arterial and venous oxylipin profiles in obese and non-obese heart failure with preserved ejection fraction (HFpEF) patients and identifies distinct obesity-associated lipid mediator patterns linked to more severe pulmonary hypertension.

A focus on using fluorinated ionic liquid stationary phases to analyze forever chemicals.

Using liquid chromatography–mass spectrometry (LC-MS) and machine learning, researchers identified distinct steroid hormone patterns in chronic versus episodic cluster headache that may help differentiate disease subtypes and point to adrenal-related involvement.

Using gas chromatography–mass spectrometry (GC–MS), researchers compared volatile flavor compounds formed in chicken breast treated with free iron, heme iron, and hemoglobin, showing that each iron type alters fat oxidation pathways and resulting aroma profiles differently.

Gas chromatography–olfactometry–mass spectrometry (GC-O-MS) combined with a Sensomics approach showed that laboratory and pilot-scale pervaporation produce grape spirits with highly similar aroma profiles and no significant differences in key odor-active compounds or consumer preference.

Using pyrolysis gas chromatography-mass spectrometry (Py-GC–MS) to measure micro- and nanoplastic levels in blood, researchers found that higher exposure in young adults was associated with increased immune cell activation but showed no link to lung function.

Using ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–MS) analysis, researchers quantified choline and betaine levels in maternal and cord blood and found that higher betaine exposure during pregnancy was associated with lower birthweight and reduced risk of excessive fetal growth.

Using gas chromatography-mass spectrometry (GC–MS) and gas chromatography with flame ionization detection (GC-FID), researchers identified carvone and limonene as the dominant compounds in caraway essential oil and showed that chitosan nanoparticle formulations improved microbial stability, reduced oxidation, and maintained the sensory quality of refrigerated pork sausages.

Using ultra high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS), researchers characterized pressurized liquid extracts of artichoke by-products and identified a diverse range of phenolic and flavonoid compounds, including caffeoylquinic acid derivatives, obtained through a greener extraction approach.

LCGC International spoke to David Bishop of the University of Technology Sydney about a new ruthenium-based tyramide amplification tag that combines fluorescence imaging with mass spectrometry imaging to improve detection and quantification of low-abundance proteins in tissue samples.

The week’s highlights include a four-part interview with Koen Vanhoutte of Johnson & Johnson Innovative Medicine on building more sustainable and efficient analytical laboratories, alongside stories on self-optimizing LC workflows, chromatography-based orange juice debittering, pesticide transformation during apple digestion, LC–MS/MS vitamin D profiling in breast cancer patients, and approaches for monitoring microbial spoilage in refrigerated meat.

Gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses demonstrate that walnut septum extracts exhibit habitat-dependent compositional variability in amino acids and phenolics, which correlates with differences in antimicrobial activity against Gram-positive and Gram-negative bacteria.

Advanced gas chromatography analysis reveals that palladium-based catalysts effectively reduce chlorine in polyvinyl chloride (PVC)-derived pyrolysis oil, improving its suitability for cleaner fuel applications.

An optimized ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method with tailored sample preparation enables accurate simultaneous detection of 30 PFAS compounds in seawater, sediment, and suspended particles, revealing their distribution and variability across marine environments.

Gas chromatography (GC) of collected surgical emissions shows that a simple closed-circuit transurethral resection (TUR) system can reduce exposure to harmful smoke compounds during prostate surgery.

Using headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) and solid phase microextraction-GC-mass spectrometry (SPME-GC-MS) coupled with multivariate modelling, researchers correlated meat volatile profiles with microbial counts to enable rapid, chromatography-based assessment of spoilage and shelf-life.

Researchers used liquid chromatography–mass spectrometry (LC–MS) to analyze hormone profiles in elite athletes, finding that some athletes with XY differences in sex development (DSD) showed testosterone patterns more similar to male athletes, helping improve understanding of conditions such as androgen insensitivity syndrome and 5α-reductase type 2 deficiency in competitive sports.

Using chromatography–mass spectrometry with ultrasound- and enzyme-based extraction methods, researchers showed that selenium speciation and recovery in broccoli sprouts depend on the extraction approach, providing insight into plant selenium uptake and metabolism relevant to food biofortification.

Using liquid chromatography-tandem mass spectrometry (LC–MS/MS) to measure pre-treatment vitamin D levels, researchers found that low vitamin D is associated with a higher risk of severe paclitaxel-induced nerve damage in breast cancer patients.

Using high-performance liquid chromatography-mass spectrometry (HPLC–MS) alongside bioassays and microbiota analysis, research has shown that gastrointestinal digestion alters the chemical fate, bioaccessibility, and toxicity of pesticides in apples in a compound-dependent manner.

A chromatography-based, non-heat process removes bitterness from orange juice while preserving its flavor and nutrients. LCGC International spoke to Araceli Rivera‑Pérez, lead author of the paper that resulted from its development.

Using thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS), researchers identified hundreds of wildfire smoke chemicals trapped in firefighter respirator filters and carbon cartridges, including several toxic compounds, highlighting the need for improved respiratory protection design.

Recent highlights in chromatography and mass spectrometry showcased advances in environmental monitoring, biomedical analysis, materials testing, textile safety, planetary science, and scientific communication, demonstrating the expanding impact of LC–MS and GC–MS technologies across research fields.

Rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of wastewater samples across England revealed widespread and fluctuating community drug use patterns—particularly high cocaine and ketamine levels—highlighting the power of chromatography-based methods for real-time public health monitoring.

High-performance liquid chromatography (HPLC) analysis showed that the peel of the citrus fruit bushukan contains low levels of key flavonoids, highlighting that presumed health benefits of citrus peels should be confirmed through species-specific chemical testing rather than assumed from fruit type.

Using targeted liquid chromatography–tandem mass spectrometry (LC-MS/MS), researchers showed that many sphingolipid levels rise with age and differ between men and women, highlighting the need for age- and sex-specific reference ranges before these markers can be used in routine health risk assessment.