Building on the initial discovery of unidentified extractable organic fluorine (EOF) in Greenland killer whale blubber, researchers characterized EOF in additional specimens and identified some of their origins using gas chromatography-atmospheric pressure chemical ionization-high resolution mass spectrometry (GC-APCI-IMS).
LCGC International spoke to Szabolcs Fekete of Waters Corporation, corresponding author of a recent paper which introduces and validates a novel separation quality factor (SQF) metric, designed to overcome the limitations of existing performance descriptors by integrating multiple normalized and weighted criteria into a single score.
Researchers from the University of Campinas (Campinas, Brazil) and the Waters Research Center (Budapest, Hungary) introduced a rapid, automated method using laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS) with high-resolution mass spectrometry to fingerprint coffee samples and predict sensory properties. LCGC International spoke to Leandro Wang Hantao of the University of Campinas regarding their work and the paper that resulted from it.
Researchers from institutions in Kenya used both morphological and molecular techniques for taxonomic identification, a disk diffusion method for bioassay analysis, and gas chromatography–mass spectrometry (GC-MS) to identify and quantify different compounds in the extracts of marine sponge samples.
Researchers in Malaysia examined the effects of Kelulut honey on metabolic syndrome (MetS)-induced osteoporosis in male rats fed a high-carbohydrate high-fat (HCHF) diet, with chemical profiling of the honey was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods.
LCGC International spoke to Maria Hayder, corresponding author of a recently published paper (1) discussing a novel workflow for nanoplastic analysis in environmental water samples, incorporating asymmetrical-flow field-flow fractionation coupled with multiangle light scattering (AF4-MALS) and pyrolysis–gas chromatography-mass spectrometry (Py-GC-MS) in an offline combination.
Researchers at the Université de Montréal evaluating the pharmacokinetics and pharmacodynamics of a single oral dose of trazodone in laboratory rabbits determined plasma concentrations of the drug with high performance liquid chromatography-mass spectrometry (HPLC-MS).
Researchers at the University of Johannesburg investigated the potential of orotate phosphoribosyl transferase (URA5) to detoxify patulin in apple juice under controlled condition, with liquid chromatography-mass spectrometry (LC-MS) used to monitor degradation.
Researchers used orthogonal analytical methods, including anion-exchange chromatography (AEC), to investigate the impact of successive freeze/thawing cycles on the stability of the Covid vaccine ChAdOx1-S/nCoV-19.
Researchers in Japan characterized heat-induced chemical modifications and changes in the molecular size distribution and structure of liquid transfer proteins, using size-exclusion chromatography (SEC) and liquid chromatography-mass spectrometry (LC-MS).
LCGC International sat down with Daniel Petras to discuss persistent challenges in non-targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite annotation, where only a small fraction of acquired spectra match existing libraries, and how the multiplexed chemical metabolomics (MCheM) workflow introduces functional group-specific derivatization to generate orthogonal chemical data.
A study conducted by the Georgia Bureau of Investigation Division of Forensic Sciences, (Decatur, Georgia) validated a salt-assisted liquid–liquid extraction (SALLE) with liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for detecting amphetamine-type stimulants (ATS) and cocaine metabolites in forensic toxicology. LCGC International spoke to Jon Stephenson of the Georgia Bureau of Investigation Division of Forensic Sciences about the study and the resulting paper inspired by it.
A recent joint study between Linköping University and the Department of Forensic Genetics and Forensic Toxicology of the National Board of Forensic Medicine (both in Linköping, Sweden) demonstrated a 32-element metal oxide semiconductor (MOS)-based e-nose, integrated with advanced supervised machine learning (ML) algorithms, for forensic applications including distinguishing human vs. animal samples, postmortem vs. antemortem states, and estimating postmortem intervals. LCGC International spoke to Donatella Puglisi, associate professor at Linköping University, and corresponding author of the paper that resulted from this work.
A recent study investigated early post-mortem volatile organic compounds (VOCs) from human donors in an outdoor environment. Using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF-MS)—a first for early post-mortem human VOC profiling outdoors—the research aims to track VOC changes, pinpoint the ante-mortem to post-mortem odor transition, and improve scent detection dog training strategies. LCGC International spoke to Darshil Patel, of the University of Windsor and lead author of the article published about his team’s findings.
J. Tyler Davidson of the Department of Forensic Science at Sam Houston State University (Huntsville, Texas) used liquid chromatography-electrospray ionization-tandem mass spectrometry (LC–ESI–MS/MS) to structurally characterize 38 nitazene analogs and propose fragmentation mechanisms that generate diagnostic product ions for analog differentiation. LCGC International spoke to Davidson about his work, and the paper that resulted from it.
Researchers studying tear-lipid fingerprints associated with aqueous-deficient dry eye (ADDE) and Meibomian-gland dysfunction (MGD) in women profiled the tear lipids with ultra high-performance liquid chromatography-mass spectrometry (UHPLC-MS).
Research regarding the connection between sodium intake and cadiometabolic risk used ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for metabolite identification.
Australian researchers set out to determine the chemical composition of anabolic–androgenic steroid (AAS) sold there, specifically to determine the presence and purity of active ingredients and evaluate the presence of cutting agents, residues, or heavy metals. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) were among the techniques used in their study.
Researchers aiming to investigate the value of serum vitamin D3 levels in patients with a history of malignancy and confirmed lung metastases measured serum Vitamin D2 (25-hydroxyergokalciferol) and D3 (25 hydroxycholekalciferol) levels were measured using high-performance liquid chromatography (HPLC).
LCGC International spoke to Dave Abramowitz, from the unified product management and product ownership team for chromatography and mass spectrometry software at Thermo Fisher Scientific, about the advantages, challenges, and future potential of AI in chromatography, highlighting how scientists can begin adopting AI-driven tools to improve accuracy, efficiency, and discovery.
Researchers from Iraq, Iran, and Italy analyzed 16 polycyclic aromatic hydrocarbons (PAHs) in grilled beef, kebab, and chicken using magnetic solid-phase extraction with gas chromatography-mass spectrometry (MSPE-GC-MS).
Researchers at the University of the Basque Country, along with Català Restauradors S.L. analyzed the emergence of soluble salts on mural paintings in the vault of the Valencia Cathedral, using ion chromatography coupled with Raman and micro-energy-dispersive X-ray fluorescence spectroscopy.
Researchers quantified urinary cotinine levels in children with asthma, analyzed correlation with asthma severity, and examined the relationship between parental smoking and urinary cotinine levels. Cotinine analysis was conducted using high-performance liquid chromatography (HPLC).
Researchers at Japan’s National Research Institute of Brewing used ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) to analyze the metabolome of sake and build predictive models of its sensory characteristics.
A joint study between York University and the University of Tehran evaluated conventional analytical methods, such as gas chromatography (GC), high-performance liquid chromatography (HPLC), and mass spectrometry (MS), as well as other emerging portable PAH detection technologies in hopes of significantly improving the health and safety of firefighters by reducing their long-term risks of cancer.
Researchers employed reflectance spectrometric analysis to quantify species-specific plumage coloration, and high performance liquid chromatography (HPLC) to elucidate the feather carotenoids of South Asian flameback woodpeckers to assess their pigment chemistries and genomic underpinnings.
A recent paper published in Parasites & Vectors presented a simplified gas chromatography-mass spectrometry-electroantennographic detection (GC-MS-EAD) setup for the detection of the volatile organic compounds (VOCs) emitted by a healthy dog and that elicit antennal responses in P. perniciosus sand flies.
A recent study employed three brands of commercially available ready-to-heat roasted catfish to investigate the off-flavor substances present after reheating, utilizing gas chromatography-electronic nose (GC-E-Nose), GC-ion mobility spectrometry (GC-IMS), and GC-olfactory-mass spectrometry (GC-O-MS )in conjunction with sensory omics.
Researchers evaluated metabolic abnormalities in six neonatal Noma foals that died shortly after birth, using laboratory tests, pathological examinations, serum amino acid (AA) analyses, genetic analyses, and gas chromatography-mass spectrometry (GC-MS).
LCGC International spoke with Aristeidis S. Tsagkaris, associate professor in the Department of Food Analysis and Nutrition at the University of Chemistry and Technology in Prague (Czech Republic), about his team’s study analyzing 19 Italian-grown chili pepper varieties using ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
