Gas chromatography–mass spectrometry (GC-MS) revealed that a stepwise precooling method better preserves key flavor-related aldehydes and esters in cherry tomatoes compared to conventional single-step cooling, helping maintain aroma quality during storage.
Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers mapped where sugar-related collagen crosslinks occur in human bone and found site-specific differences in their distribution and only weak links to bone strength.
Using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) alongside sensory tools, researchers showed that different cooking methods systematically alter the chemical compounds—and therefore the flavor profile—of Yuxiang shredded pork.
Using gas chromatography–mass spectrometry (GC–MS), researchers showed that low, non-lethal exposure to deltamethrin alters key fatty acids in honey bee brains, indicating disrupted neural metabolism that may underlie pesticide-related cognitive effects.
A recent study developed and validated a highly sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) fluorescence method using OPA/ethanethiol derivatization to simultaneously quantify multiple gentamicin C-subtypes in tiny murine perilymph samples, enabling improved pharmacokinetic analysis in the inner ear. LCGC International spoke to Shreshtha Dash and Peter Streyger, two of the authors of the paper that resulted from this study,1 about their work.
Using gas chromatography–mass spectrometry (GC-MS) aboard the Curiosity rover, scientists have identified more than 20 organic compounds in ancient rocks from Gale Crater, revealing a diverse mix of carbon-based molecules and helping advance the search for the origin—and possible biological significance—of organic matter on Mars.
From a preview of HTC-19 in Leuven to cutting-edge insights from analytica 2026, this week’s highlights span breakthroughs in environmental screening, non-invasive diagnostics, green analytical methods, and emerging biomarkers for adolescent mental health.
Liquid chromatography-tandem mass spectrometry (LC–MS/MS) hair analysis combined with surveys at a Portuguese music festival revealed frequent drug use, discrepancies with self-reports, and widespread polydrug exposure, demonstrating chromatography’s value for objective, long-term substance use assessment in high-risk settings.
Using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics, researchers identified obesity-linked biomarkers, highlighting hexanoylglycine and LPC (16:0) as potential causal indicators tied to immune pathways and cardiometabolic risk.
Researchers used high-performance liquid chromatography (HPLC) to identify how 19 breast milk sugars shape healthy gut bacteria in 500 infants, discovering age-specific impacts that persist even after breastfeeding ends.
Ultra-performance liquid chromatography–high-resolution mass spectrometry (UPLC-HRMS) was used to profile metabolomic changes during papain- and bromelain-mediated hydrolysis of gourami fish proteins. Distinct time- and enzyme-dependent profiles revealed differences in proteolysis and metabolite release, highlighting strategies to optimize bioactive peptide production and enhance the nutritional functionality of fish-derived food products.
Researchers used gas chromatography-mass spectrometry (GC-MS) and chemometric analysis to identify 54 metabolites in commercial lavender oils, identifying quality markers like linalool and detecting potential adulteration with synthetic additives.
Small extracellular vesicles (EVs) from pericardial fluid (PF) of patients with and without CAD alter the lipid profile of human coronary artery endothelial cells. Using untargeted liquid chromatography–mass spectrometry (LC-MS), 1043 lipid species were identified, with changes in glycerophospholipids, glycerolipids, and sphingolipids. These results suggest PF EVs can influence endothelial lipid metabolism and may impact coronary artery function.
Researchers utilized advanced chromatography techniques to reveal that disrupted metabolic pathways and oxidative stress cause flavor deterioration and unpleasant off-taste in wooden breast chicken meat.
Researchers used liquid chromatography-high resolution mass spectrometry (LC-HRMS) to identify blood metabolites linked to teen mental health, offering a potential objective tool for early risk detection and preventive care.
ChromatographyOnline.com marked Earth Day with environment-focused content and expert interviews while also highlighting advances in chromatography, including sustainable methods, GC×GC–MS for complex materials, and managing HRMS data complexity.
Researchers developed a solid phase extraction liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method enabling sensitive chromatographic separation and quantification of eight steroid hormones in ≤50 mg whale blubber. The approach achieved low detection limits, reliable measurements across species, and supports conservation by assessing stress, metabolism, and reproductive status from minimal sample material.
Liquid chromatography–mass spectrometry (LC-MS) was used to evaluate the stability of ethanol-free buprenorphine formulations in compounded oral syringes over 60 days. Chromatographic analysis showed no degradation products and consistent drug concentrations, supporting formulation stability and safety while highlighting the role of LC–MS in pediatric pharmaceutical quality assessment.
Researchers used high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to demonstrate that atmospheric cold plasma (ACP) effectively removes up to 82.5% of toxic fenvalerate residues from shiitake mushrooms. The study identified degradation pathways like hydroxylation and ester bond cleavage. ACP offers a promising, non-thermal solution to enhance food safety and preserve mushroom quality during storage.
Researchers developed an advanced gas chromatography approach that allows direct analysis of recycled plastics with minimal preparation. This method uses thermal desorption to efficiently detect volatile contaminants, making it faster and more practical for routine quality control.
High-performance liquid chromatography (HPLC) was utilized by researchers to measure plasma hydrogen sulfide (H₂S) in patients with schizophrenia. The study revealed that after antipsychotic treatment, elevated H₂S levels—accurately determined via HPLC—correlated significantly with improved memory, highlighting H₂S signaling as a key factor in understanding cognitive impairment.
Researchers used tandem mass tagged quantitative liquid chromatography tandem mass spectrometry (TMT-LC-MS/MS) to analyze plasma from exposed loggerhead and Kemp's ridley turtles, identifying altered immune proteins as biomarkers for brevetoxicosis, aiding diagnosis amid intensifying blooms.
LCGC's "Earth Day" coverage examines a advanced mass spectrometry method to accurately measure PFAS and trace pharmaceuticals in wastewater.
Our "Earth Day" coverage continues with a look at how LC-HR-MS/MS can track how human-made chemical pollution is harming ocean ecosystems.
Our "Earth Day" coverage examines a study using fluorinated ionic liquid stationary phases to analyze forever chemicals.
Drug testing of non-biological samples revealed a new nitazene opioid, N-pyrrolidino fluetonitazene, in a nasal spray. Researchers used gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) alongside other methods to confirm its identity. The finding highlights evolving drug trends, serious health risks, and the need for up-to-date analytical techniques despite limited sample size.
Liquid chromatography–mass spectrometry (LC-MS) enabled comprehensive profiling of metabolites produced by cucumber glandular trichomes across developmental stages. Analysis identified 744 compounds, dominated by flavonoids, and revealed ecotype-specific variations. Chromatographic insights into trichome secretions link metabolite composition to fruit bloom formation and support future crop improvement and natural product applications.
Ion chromatography and 16S rRNA sequencing were applied to evaluate seasonal nutrient removal and microbial dynamics in an A2O wastewater treatment plant. Results showed temperature-dependent nitrifier reductions impacting efficiency, while downstream monitoring revealed transient microbial influence on river systems, highlighting chromatography’s role in linking nutrient chemistry with ecological outcomes.
A research study recently introduced a streamlined, chromatography-compatible workflow for the rapid analysis of RNA modifications by integrating solid-phase enzymatic digestion with downstream liquid chromatography–mass spectrometry (LC–MS). LCGC International spoke to Yixuan (Axe) Xie, an assistant professor at Fudan University (Shanghai, China) and one of the authors of a paper resulting from this study.
Researchers explored the potential of Prunus laurocerasus (cherry laurel) and Prunus cerasifera (cherry plum) fruit pits as natural food additives. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed that the extracts were found safe for healthy cells, selectively targeted certain cancer cells, and showed strong antioxidant and enzyme-inhibiting activities, including anti-browning effects. These findings highlight the pits’ promise as sustainable, functional food ingredients.
