LCGC North America-06-01-2018

Click the title above to open the LCGC North America June 2018 regular issue in an interactive PDF format.

What can metal–organic frameworks offer for liquid chromatography?

Here, we see how 2D-LC can solve coelution problems that are difficult or impossible to address using peak purity tools or curve resolution methods.

Comprehensive characterization of ADCs requires increasingly powerful approaches consisting of small- and large-molecule techniques.

To ensure the reliable and accurate characterization of biotherapeutics, an arsenal of orthogonal analytical techniques is needed.

With autosamplers, we need to be extra careful to avoid contamination.

Comprehensive 2D-LC using HILIC and reversed-phase LC is a robust tool to characterize nonionic ethoxylated surfactants in pharmaceutical formulations.

We examine the connection between the distribution coefficient and Gibbs free energy, and contributions from enthalpy and entropy.

Drug discovery can be accelerated by chromatographic profiling of analogs by measuring their nonspecific binding to proteins and lipids.