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Now you can get comprehensive repair, maintenance and compliance support for all major LC, GC and MS models in your lab regardless of manufacturer.

Parabens (esters of para-benzoic acid) are widely used as food additives and synthetic preservatives in cosmetics and personal care products, and in pharmaceutical formulations. Common types include methyl paraben (E218), ethyl paraben (E214) and propyl paraben (E216).

The 1,4-benzodiazepines constitute an important class of psychotherapeutic agents known for their hypnotic, tranquilizing and anti-convulsant properties. Comprehensive research has been performed to study their clinical performance (1).

At a time when the conference and symposium industry seems to be dominated by giants such as Pittcon and ASMS, it is refreshing to find a thriving boutique conference like the 9th Annual Csaba Horvath Symposium held April 28?29 at the Hartford Convention Center in Hartford, Connecticut.

The answer to the following question was provided by LCGC's "LC Troubleshooting" columnist John Dolan.

Q&A Is Green the New Black? Chris Welch from Merck's Separation and Purification Centre of Excellence in Rahway, New Jersey, USA spoke to Alasdair Matheson about the renewed interest in green chromatography and the role supercritical fluid chromatography will play in this Quantification of Pharmaceuticals from Diminishing Small Volumes of Blood Using the UHC Small Molecule Chip Coupled to Triple Quadrupole MS Stephan Buckenmaier, Adrien Bonvie and Corinne Emotte An investigation of the Impact of Common Experimental Parameters on Signal Intensity in SFC–ESI-MS Lakshmi Subbarao, Jacquelyn Cole and Rui Chen Multicolumn Preparative SFC: An Advanced Solution to Scale-up Difficulties Zahid Ali, Jelena Kocergin and Vinay Edwin Introduction to HPLC 2009 Christian Huber HPLC 2009 Guide In preparation for this year's show, our HPLC 2009 guide provides exhibitor and programme information, a floorplan plus a city guide on what to see, where to eat, drink and shop and useful phrases to help you get by. News A company's environmental management system, canine training, protein analysis to answer evolutionary questions and a community award are in the news this month. Market Trends and Analysis Separations in the Food Industry Glenn Cudiamet Incognito 'ILICs' Everywhere This month Incognito examines the hype surrounding hydrophillic interaction chromatography as the 'new' best thing in HPLC to determine whether this separation technique is all it's cracked up to be.

Chromatographic Society Spring Symposium

Improved Separation of Blood Alcohols Using Zebron? ZB-BAC1 and BAC2 GC Columns-Phenomenex Application Note

An overview of the most effective 2D–LC methods to separate complex peptides is discussed.

Two-dimensional liquid chromatography (2D-LC) allows analysts to deal with complex samples that either cannot be adequately separated by one-dimensional liquid chromatography (1D-LC) or require excessively long analysis times. Peptide mixtures, whose characterization is relevant in many areas (e.g., proteomics, food analysis, pharmaceutical, life sciences), are a clear example of such complexity. An overview of the most used 2D-LC modes of operation is presented and several examples of their use for the separation of peptide mixtures are described.

TSK-GEL ODS-140HTP, 2.3?m Columns for the Fast and Reliable Separation of Drugs Used in Cold and Sinus OTC Medicines-Tosoh Application Note

2 Ways to Attain Sharper Peak Shape and Higher Sensitivity in Gas Chromatography-Phenomenex Application Note

How are the signal-to-noise ratio and imprecision related?

Digital Update

The authors discuss the use of high-resolution LC-MS to analyze complex samples in regulated environments such as food and animal-feed analysis.

There is a misconception in the chromatographic community that polar analytes cannot be analysed using SFC because they are not soluble in carbon dioxide.

Designed by The National Endowment for Science Technology and the Arts (NESTA) the Crucible programme brought together 30 researchers from across the disciplines of science and social science for the first of four innovation camps with the aim of developing new ideas and explore the wider potential that interdisciplinary collaboration can bring to their work.

Supercritical Fluid Chromatography (SFC) has been practiced for approximately 50 years. SFC on packed columns for both qualitative and quantitative purposes underwent a renaissance in interest at the beginning of the 1990s when limitations of capillary SFC became obvious and important progress in composition gradient techniques for mixed mobile phases was achieved. Even with these instrumental improvements, wide acceptane of the technology was not forthcoming because the perception was that highly polar analytes were not soluble in carbon dioxide and thus were not separable. It is now apparent that the use of additives dramatically extends the range of solute polarity amenable to SFC.

Routine HPLC Determination of Aminopyridine Compounds-ESA Application Note

Thermo Fisher Scientific has announced that it will acquire Biolab, a leading provider of analytical instruments, life science consumables and laboratory equipment for scientific, environmental and healthcare markets in Australia and New Zealand.

A study led by cancer researchers at Ohio State University's Comprehensive Cancer Center's Experimental Therapeutics Program.has validated a method for reliably measuring variations in certain proteins that may make good biomarkers in chronic leukemia patients.

Analtech (Newark, Delaware) announced the launch of a web blog dedicated to thin-layer chromatography (TLC).

Thermo Fisher Scientific (Waltham, Massachusetts) has agreed to acquire Biolab, an Australian analytical instruments and life science consumables distributor, for $120 million (US).

Scientists from Brigham Young University (Provo, Utah) and US Synthetic Corporation (Orem, Utah) developed C18, C8, and perfluorinated diamond-based reversed-phase solid-phase extraction (SPE) media.

Researchers from the Research Institute for Chromatography (Kortrijk, Belgium) and AstraZeneca R&D Charnwood (Loughborough, UK) used in-situ derivatization and liquid chromatography?mass spectrometry (LC?MS) to analyze arylamines and aminopyridines, which can be present as potentially genotoxic impurities in pharmaceutical preparations at trace levels.

The authors discuss the use of GC-MS in drug doping testing.

Thermo Fisher Scientific?s (Waltham, Massachusetts) Cambridge, UK, facility has been awarded the Queens Award for Enterprise 2009 in the Outstanding Innovation category for its iCAP 6000 Series inductively couple plasma?optical emission spectrometry (ICP?OES) system.

Nucleotide Bases with Excellent Peak Shapes-Microsolv Application Note