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The Pittsburgh Conference announced today that Dr. Leroy Hood will deliver the plenary lecture, Systems Biology and Systems Medicine, during the Opening Session of Pittcon 2008 at the Ernest N. Morial Convention Center, New Orleans, LA on March 2, 2008.

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LCGC 2007 Buyers' Guide

LCGC North America welcomes manuscripts that describe techniques and applications of all forms of chromatography and capillary electrophoresis and that are of immediate interest to users in industry, academia, and government.

Eksigent enters Latin America

This month's Technology Forum looks at the topic of Software/LIMS and the trends and issues surrounding it. Joining us for this discussion is Kim Shah, Director of Marketing and Business Development for Informatics at Thermo Fisher Scientific, John Helfrich Director of GMP Lab Automation Programs at VelQuest Corporation, and Donna Lococo, Enterprise Software Solutions Product Leader at PerkinElmer Life and Analytical Sciences.

One issue that has become clear to us throughout courses, workshops, seminars, and various talks on the subject of method validation, is that while many people talk the language, sometimes the individual method validation terms mean different things to different people. While the actual protocols, or experimental details used to measure or evaluate method validation can vary, it's a good idea to have a common understanding of the underlying terms. In this month's installment of "Validation Viewpoint," we have compiled glossary of method validation terms as they pertain to chromatography.

Thermo Fisher Scientific, Inc., (San Jose, California) announced it has acquired all assets of the OptiCell product line from BioCrystal, Ltd. (Westerville, Ohio).

Senior chemist for the LC Columns and Supplies Division of Agilent Technologies (Palo Alto, California) and LCGC columnist Ron E. Majors was awarded the L.S. Palmer Award by the Minnesota Chromatography Forum (MCF) for his outstanding contributions to chromatography.

Eskigent (Dublin, California) announced a new distribution agreement with Nova Analitica of Brazil.

Shimadzu Scientific Instruments (Columbia, Maryland) announced the opening of a new regional office in Carlsbad, California.

Thar Instruments (Pittsburgh, Pennsylvania) announced the acquistion of Berger SFC division of METTLER TOLEDO (Columbus, Ohio).

This article demonstrates that screening of several hundred possible pesticides is now feasible with one ESI-TOF MS run.

Phenomenex, Inc., a global leader in the separation sciences business, has been notified by R&D Magazine that it has won the coveted R&D 100 Award for the second year in a row.

In order to answer demand for their rapidly growing product line, LECO's entire Separation Science group relocated to its brand new Life Sciences & Chemical Analysis Centre on July 12, 2007.

Arnel Inc. recently the opening of its new sales office in Bangkok, Thailand.

Thar Instruments, a global leader in the design, development and manufacture of Supercritical Fluid Chromatography (SFC) systems announced the acquisition of Berger SFC? division of METTLER TOLEDO. Berger SFC? is a pioneer in the development of SFC and a world leader in SFC Analysis and Purification.

Industrial-Scale Chromatography: A Cost- and Time-Effective Purification Solution Jean Blehaut, Eric Valery and Francois Romelaer Dalian ISCC 2007 Review A look back at this year's event which marked the first international conference on chromatography to be held in China. News All the news from August 2007. Do We Really Need Consultants? Zosimus wonders if consultants offer advice scientists can actually manage without. Market Trends & Analysis Glenn Cudiamat reports on worldwide ion chromatography demand. Q&A: It's A Small World Peter Dawes, chairman of SGE Analytical Science, talks about the benefits and application of microextraction by packed sorbent (MEPS).

EuroAnalysis has established itself as the central forum for discussion and presentation of activities for analytical chemistry in Europe.

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The acid-base constants of the most frequently used antianginals (diltiazem, nadolol, propranolol and verapamil) were determined using capillary zone electrophoresis (CZE). This method is based on measuring the electrophoretic mobility of the solute as a function of pH. The buffer employed was composed of borate-phosphate buffered across the pH range of 3.0–11.2. The acid-base constants were determined by performing linear and non-linear regression on the data obtained. The results were compared with those reported in literature and with those obtained by a spectrophotometric method. After comparison of the values, no significant differences were observed between the three acid-base constants.

After a 25-year dormant period, chromatography was finally reborn in the first years of the 1930s.

Waters and Rosetta Biosoftware collaborate; Eksigent reaches Southeast Asia distribution agreement; Phenomenex reaches distribution agreement with Beckman Coulter; The Pittsburgh Conference announces call for papers; Agilent Technologies acquires Stratagene

Here we describe a new compact device for electron-capture dissociation (ECD) analysis of large peptides and posttranslational modifications of proteins, which can be difficult to analyze via conventional dissociation techniques such as collision-induced dissociation (CID). The new compact device realizes ECD in a radio frequency (RF) linear ion trap equipped with a small permanent magnet, which is significantly different than the large and maintenance-intensive superconducting magnet required for conventional ECD in Fourier-transform ion cyclotron resonance mass spectrometers. In addition to its compactness and ease of operation, an additional merit of an RF linear ion trap ECD is that its reaction speed is fast, comparable to CID, enabling data acquisition on the liquid-chromatography (LC) time scale. We interfaced the linear-trap ECD device to a time-of-flight mass spectrometer to obtain ECD spectra of phosphorylated peptides injected into a liquid chromatograph, infused glycopeptides, and intact small..

More than 20 years passed after the introduction of Fourier transform–ion cyclotron resonance mass spectrometry (FT-MS) before advancements in electronics and computer technology enabled the development of practical, high-performance instruments. Modern analytical FT-MS instruments rely on sophisticated electronic circuitry and powerful computer software to achieve the dramatic resolving power and mass accuracy typical for the instrumentation. Here, the power of modern hybrid FT-MS instrumentation is discussed by demonstrating the capability of this instrumentation for selected applications such as the analysis of crude oil, intact protein, and fragile noncovalent complex samples.

Assay sensitivity is the lowest concentration at which a targeted analyte can be measured and is often limited by chemical background or co-eluting interferences. FAIMS in combination with liquid chromatography (LC) and zero neutral loss tandem MS was used to remove chemical background and co-eluting interferences from the analysis of linoleic acid in cancer cell extracts. Concentration of endogenous linoleic acid was determined from back-calculation of standard calibration samples fortified with deuterium-labeled linoleic acid. No internal standard was used. LC–MS-MS analysis of the cancer cell extracts resulted in an increase in signal-to-noise ratio of 10-fold. The assay sensitivity was increased 10 times over the traditional LC–MS-MS experiment exclusively due to the new FAIMS technology.

Metabolomics is a developing analytical approach that is growing rapidly in importance as a tool to improve diagnosis and treatment of disease, as well as to speed up the drug development process. Unlike genomics or proteomics, which only reveal part of what might be happening in a cell, metabolomic profiling can give an instantaneous snapshot of the entire physiology of that cell. This article describes the challenges associated with metabolomics research and new tools developed to overcome them.

Reproducing analysis conditions is crucial to achieving consistent, accurate results in gas chromatography–mass spectrometry (GC–MS). Valid reproduction demands appropriate application of technique, solid method design, reliable and accurate equipment, and a dedicated team of well-practiced technicians and researchers. But even when all these conditions are met, users can be held back by the more subtle elements in GC–MS operations, such as cutting or changing a column, or setting up the same experiment on different equipment. Even getting the parameters of a test organized so that it can be reproduced elsewhere - in a laboratory across the hall, the country, or the world - can be daunting. Consistent GC–MS results depend upon retention-time reproducibility.