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On behalf of New Objective, I extend my warm congratulations to LCGC in this, its historic 25th-year anniversary. New Objective shares in celebration, as we reach our own 10-year milestone in 2007. Back in 1997 when New Objective made its debut as a two-person corporation, personal risks were high, and the practice of applying nanobore reverse-phase chromatography and (nano)electrospray-enabled mass spectrometry was in its infancy. This past decade enabled us to participate in the growth, acceptance, and demand for both ion-trap and quadrupole time-of-flight mass spectrometry as definitive vehicles for high-sensitivity protein characterization and the now burgeoning field of proteomics.

Polymicro Technologies, LLC, Phoenix, Arizona, has been manufacturing capillary tubing for GC since the company was formed in 1984 as a spin-off of the Raychem Corporation.

PerkinElmer has been an innovative pioneer in chromatography for over 50 years. Recognizing the demand for increased laboratory productivity and improved analytical capability, PerkinElmer has responded by delivering a number of technology advancements in both its GC and LC systems using the latest tools and technologies. These advancements allow scientists to run existing and new applications faster as well as enable fast chromatography without compromising performance.

To discuss LCGC's influence on MicroLiter's success, I have to back up five years or so and tell you how I entered this market. My degree is in advertising design. I have worked with regional advertising agencies and was at a very large international advertising agency, producing graphics for a variety of industries. I came into this industry as a business owner producing advertising for a fledgling autosampler vial company, National Scientific Company (NSC). I was contacted by a photographer friend of mine who owns Woody Williams Photo, who had attended Pittcon in Atlanta in the late 1980s. He had met the owner of NSC on the show floor, and he communicated to Woody that he had a new product he wanted to introduce and needed an advertisement produced for his industry's primary trade publication, LCGC.

Restek Corporation was founded in 1985 as a gas chromatography column manufacturer in a small business incubator in Pennsylvania.

Absolute Standards, Inc. is an industry leader in providing certified reference materials, quality control standards, and performance testing samples to the analytical testing community.

SGE is a leading partner in the design and manufacture of custom solutions for original equipment suppliers, as well as an experienced consumables supplier to the analytical chemistry markets.

Waters Corporation and Northeastern University opened the doors of the Waters Mass Spectrometry Laboratory within the renowned Barnett Institute of Chemical and Biological Analysis at the University.

Latest CRADA Aimed at Developing Liquid Chromatography and Mass Spectrometry Methods for Measuring PFCs at Very Low Concentrations

Thermo Fisher Scientific Inc., and MayLab Analytical Instruments, manufacturer of LC and LC-MS multi column selection and column switching system solutions, announce the release of new software control for MayLab's MistraSwitch multi column selector for the Mistral oven with the Thermo Scientific Surveyor Plus HPLC.

LCGC Ad Performance Study Sell Sheet

News All the news from April 2007 Improved Isolation and Analysis of Mycotoxins from Cereals, Wines and Beers Elisabeth Korte, Max Erwine and Jason S. Wood Zosimus This month Zosimus asks if the time has come for conferences to go virtual Pittcon 2007 Review Beth Kirol, Pittcon 2007 President, looks back on the success of this year's event. Trace-Level Determination of Bromate in Water by Ion Chromatography Achim Rumi and Alfred Steinbach Q&A Steve Fischer, a senior applications chemist with Agilent Technologies, talks about the role of chromatography in metabolomic research.

Accurate preparation and correct selection of buffers is essential to obtain reproducible and consistent results in capillary electrophoresis (CE). A number of factors should be considered in buffer optimization, including the pKa of the buffering ion and the analyte as well as the molarity of the acid or base used in the adjusting procedure. Accurate recording of the precise reagents used and the procedures performed is necessary to prepare buffers consistently. "Poor reproducibility of results and poor quantitative precision will be attainable in CE assays without significant attention being paid to the preparation of buffers used."

Agilent Technologies Inc. (Santa Clara, California) recently announced the intent to establish an R&D center in Bengaluru, India. The center will host a multidisciplinary team for chemical analysis, molecular biology, and software for creating novel and complex scientific applications on its instrument.

The Gold Editor's Choice Awards was presented to Waters Corporation (Waltham, Massachusetts) for the Synapt HD-MS system at Pittcon 2007 in Chicago, Illinois.

With a frequency response of 90 Hz–20 kHz, these LaCie FireWire speakers deliver powerful, vibrant sound for your music, movies and games. The speakers connect easily to computers, either laptops or desktops, as well as MP3 players, using the built-in FireWire cable. FireWire provides superior digital audio as well as line power - no need for batteries or an AC adapter.

Three LC workshops will take place between 30 April and 4 May at the Chesterfield Mayfair Hotel, London, UK. The courses offer practical training aimed at improving chromatography skills to enhance laboratory performance. They are hosted by LCGC Europe in association with LC Resources and sponsored by Hichrom.

Waters Corporation (Waltham, Massachusetts) recently has announced two significant collaborations.

The 30-year history of advances in gas chromatography–mass spectrometry technology continues today. Recent improvements in hardware, electronics, and data analysis software have resulted in new levels of productivity and sensitivity that have broadened the potential applications for this laboratory mainstay.

Mass spectrometers are effective for identifying and quantifying unknown molecules, such as disease-related proteins and small molecules in pharmaceutical research and medical diagnosis. In addition, mass spectrometry (MS) can be particularly powerful when analyzing molecules with complex structures, such as posttranslationally modified proteins. Among various MS approaches, high-resolution multistep tandem MS (MS-MS) is an emerging methodology for accurate identification of complex molecules. In this article, we describe a new approach for mass analysis with enhanced quantitative capability combined with high-resolution multistep MS-MS, where the dynamic range of quantitation covers four orders of magnitude.

The ability to perform accurate mass measurements in mass spectrometry (MS) for elemental composition determination (ECD, also known as formula identification) provides a powerful tool for assisting in the identification of unknown compounds. Recent advances in data processing methods have demonstrated the ability to obtain mass accuracy in the 5–10 ppm range on routine single- and tandem-quadrupole systems (1,2), sufficient to assist in the formula identification. However, even on more expensive high-resolution systems such as quadrupole time-of-flight (qTOF) or Fourier transform (FT)–MS instruments that are capable of routinely measuring mass accuracy in the 1–3 ppm range, the formula identification is not unique, particularly for higher molecular weight compounds. By calibrating instruments to obtain high spectral accuracy as well as mass accuracy, the ability to unambiguously identify the formula is improved substantially, particularly on low-resolution systems.