In this edition of “Inside the Laboratory,” Andrew Zydney of Pennsylvania State University discusses his laboratory’s work with using high performance liquid chromatography (HPLC) to analyze biopharmaceutical products before and after membrane separation processes.
A recent study measured stress and reproductive hormones in three stocks of free-ranging bottlenose dolphins inhabiting different natural salinities across the Gulf of Mexico, with hormones extracted from the blubber of 82 remotely biopsied dolphins and quantified using ultrahigh-pressure liquid chromatography (UHPLC) coupled with orbital ion trap fusion mass spectrometry.
“Strange blobs” that started washing up on Newfoundland’s shores months ago may have been identified through a Canadian chemist’s investigation using mass spectrometry (MS).
Scientists from the Massachusetts Institute of Technology, the University of Washington, and other leading institutions took the stage at the Eastern Analytical Symposium to accept awards and share insights into their research.
After collecting dried blood spots from preterm infants with gestational age (GA) of less than 32 weeks within 24 hours after birth, researchers used liquid chromatography-tandem mass spectrometry (LC–MS/MS) to perform targeted measurements of metabolites to identify differential metabolites in preterm infants with bronchopulmonary dysplasia and uncovering circulating biomarkers for the early prediction of this chronic lung disease.
In this edition of “Inside the Laboratory,” Susan Richardson of the University of South Carolina discusses her laboratory’s work with using electron ionization and chemical ionization with gas chromatography–mass spectrometry (GC–MS) to detect DBPs in complex environmental matrices, and how her work advances environmental analysis.
Aiming to develop a comprehensive strategy for evaluating the chemical migration from various reusable plastic bottles, researchers from the University of Copenhagen utilized vacuum evaporation concentration (VEC) enrichment combined with liquid chromatography (LC) high resolution mass spectrometry (HRMS) analysis to investigate a wide range of materials from different manufacturers to identify those with higher and lower chemical migration rates.
A recent study evaluated the potential of fruit by-products from acerola, guava, and tamarind’s potential in producing fermented beverages, with their acid profiles determined by high performance liquid chromatography (HPLC).
A recent study set out to assess the significance of geographical and varietal factors in the content of alkaloids, phenolic compounds, and the antioxidant capacity of chocolate samples. Filtered extracts were analyzed by reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet (UV) and spectrophotometric methods to determine individual phenolics and overall indexes of antioxidant and flavonoid content.
The pivotal role of analytical chemistry in the medico-legal and forensic applications is explored in this article.
Liquid chromatography and tandem mass spectrometry (LC–MS/MS) was used to show that repeated stress can cause delayed but sustained changes in blood plasma proteins associated with water conservation, immune responses, fat metabolism, insulin sensitivity, iron recycling, and hormone transport in elephant seals. Some of these changes may be novel markers of recent and chronic stress exposure in marine mammals.
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LCGC International spoke to Heather Barkholtz and Maia Bates of the University of Wisconsin-Madison about their recent evaluation of a broad screening technique for high-priority drugs of abuse in whole blood.
A recent study investigated the protein composition and baking quality of 14 German common wheat landraces, with 6 modern varieties serving as a control group. The protein composition was determined using modified Osborne fractionation and reversed-phase high-performance liquid chromatography (RP-HPLC).
A look at some of the hottest topics in mass spectrometry.
Peng Che fom Vrije Universiteit Amsterdam in the Netherlands discusses the benefits of hyphenating liquid chromatography (LC) with electron activated dissociation mass spectrometry (EAD-MS) to analyze cathinone positional isomers.
A recent study examined the impurity profile of thirteen different lots of synthetic nicotine and compared them to fourteen lots of nicotine extracted from plants using in-house analytical methods, with samples tested for alkaloids and phenols with reversed-phase high-performance liquid chromatography (RP-HPLC).
A look at the practical benefits of using TIMS-TOF MS in spatial biology applications.
The aroma properties of spontaneously fermented Cabernet Sauvignon wines produced from seven sub-regions of Shangri-La, China were comprehensively analyzed using the headspace micro-extraction with gas chromatography-mass spectrometry (GC-MS), odor activity values, and olfactory evaluation.
At Analytica this year, an oral session titled “A Dream Comes True: Fantastic News from Analytical Chemistry” focused on cutting-edge techniques in separation science in Hall 5 of the International Congress Center Munich (ICM) International Congress Center Munich (ICM).
On the suggestion that per- and polyfluoroalkyl substances (PFAS) affect both lactation and the human metabolome, perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were measured in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Informative panel discussions featuring key opinion leaders from the separation science sector discussing the latest technology trends and developments in liquid chromatography, gas chromatography, sample preparation, and data handling.
A look at some of the highlights that separation scientists can look forward to at Analytica 2024.
A recent study compared different workflows for extracting, purifying, and analyzing bone proteins using liquid chromatography with tandem mass spectrometry (LC–MS/MS), including an in-StageTip protocol previously optimized for forensic applications, and two protocols using novel suspension-trap technology (S-Trap) and different lysis solutions. LCGC International discussed this work with Noemi Procopio of the School of Law and Policing and the Research Centre for Field Archaeology and Forensic Taphonomy at the University of Central Lancashire (UK), corresponding author of the paper that resulted from this study.
Recent advances in green chemistry have made multivariate experimental design popular in sample preparation development. This approach helps reduce the number of measurements and data for evaluation and can be useful for method development in gas chromatography.
With green chemistry becoming a hot topic in chromatography, researchers from the Institute for Instrumental Analytics and Bioanalytics at Mannheim University of Applied Sciences examined gas chromatography–ion mobility spectrometry (GC–IMS) as a greener alternative to GC–MS.
Here is some of the most popular content posted on LCGC International this week.
In this “Equipment Roundup,” the editors of LCGC International present SCIEX’s ZenoTOF 7600+ System and Fraunhofer Institute for Integrated Circuits’ nanoSPECTRAL chip.
In this article, the authors describe a simple workflow to develop a GC×GC method for a specific sample upon initial use, with the aim of decreasing the time to accomplish functional workflows for new users.
