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Theoretical computations can contribute input into experimental determinations.

Agilent Technologies has announced the opening of a new state-of-the-art facility for spectroscopy research and development at the Harwell Science and Innovation Campus in Oxfordshire, UK.

SepSolve Analytical Ltd has opened a state‑of‑the-art laboratory and training facility in Waterloo, Canada, to improve its service to North American customers.

Researchers attempting to overcome complex matrix interference in commercial food analysis have developed a targeted LC–MS/MS method and open source analysis software capable of identifying allergens in complex food matrices.

Sartorius Stedim Biotech (SSB) has agreed to acquire parts of Danaher’s Life Science portfolio.

Researchers have developed two new methods for the analysis of MOAHs in highly purified mineral oil fractions (white oils) using comprehensive AgLC×GC, one method uses FID, while the other uses VUV.

HTC-16 will be held from 29–31 January 2020 in Ghent, Belgium. This event preview offers a sneak peak of what to expect.

Kevin Schug delves into modern microscale liquid chromatography (LC) stationary phases.

Glycosylation is the most common monoclonal antibody (mAb) post‑translational modification. What is essential to know about it?

Click the title above to open The Column November 2019 Europe & Asia issue, Volume 15, Number 11, in an interactive PDF format.

Click the title above to open the LCGC Asia Pacific November/December 2019 regular issue, Vol 22, No 4, in an interactive PDF format.

Click the title above to open the LCGC North America November 2019 issue, Volume 37, Number 11, in an interactive PDF format.

The sample solvent can have a big impact on peak shape in both reversed-phase and hydrophilic interaction liquid chromatography (HILIC) separations, especially when large volumes are injected. Diluting the sample with weak solvent can be an effective solution to mitigate this problem, but we have to be careful to not lose analytes of interest to precipitation or phase separation.

Most manufacturers ship gas chromatographs with a small collection of consumable parts and accessories, such as extra ferrules, inlet liners, or septa, and a few instrument-specific tools. In earlier times, some convenience items might have been included as well, like a bubble flow meter or a small set of tools, but now it’s rare to find such things in the shipping boxes. This edition of “GC Connections” lists a number of essential items that should be on hand in every gas chromatography (GC) laboratory, their function, and how to use them effectively.

An excerpt from LCGC’s professional development platform, CHROMacademy.com

In this instalment of “GC Connections”, the advantages of multidimensional chromatography with HPLC as the first dimension and GC as the second are discussed.

The occurrence of additives, such as plasticizers in plastic food packaging, has been documented, but information on their potential migration into foods is limited. In this pilot study, 2D GC–MS was used to identify chemicals extracted from a common stretch plastic film with a series of organic solvents.

For decades the prevailing perception was that satisfactory re-equilibration of reversed-phase columns following gradient elution took a long time. In the early 2000s we showed that this perception was not well founded, and demonstrated that adequate re‑equilibration could be achieved in seconds. Recently, we have shown the same for HILIC columns. All of this work so far has been with small molecules. In this article, we present an overview of this work, and summarize the practical utility of it all.

The 16th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-16) will be held from 29–31 January 2020 in Ghent, Belgium.

An excerpt from LCGC’s professional development platform, CHROMacademy.com

Click the title above to open the Advances inBiopharmaceutical Analysis 2019 special issue in an interactive PDF format.

The effectiveness of a separation can be quantified by measuring the resolution. This article explains the factors influencing resolution and the equation for predicting the required number of theoretical plates to obtain a given esolution.

These three tips provide a clear starting point developing any HPLC method, to achieve optimum resolution in the minimum amount of time.

An introduction to this special issue by our guest editor

Keynote speaker Milton Lee of Brigham Young University presents “Portable Capillary Chromatography.”

Gulf Coast Conference keynote speaker Tyler Cohen Wood, who is an internationally recognized cybersecurity influencer and authority, presents “Cybersecurity-The New Frontier in Protecting Critical Infrastructure.”

Andy Boyd of the University of Houston presents “Data Handling and Analytics: A Case Study Using Airline Ticket Pricing as Told through Data and Deregulation.”

Hundreds of therapeutic mAbs and ADCs are in development. Detailed analytical characterization of these proteins is essential for ensuring product quality and safety. This LCGC ebook on Workflow Solutions for Optimizing Native ADC and mAb Analysis covers how advancements in SEC, HIC, and other techniques are helping analytics achieve better results.