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The sample solvent can have a big impact on peak shape in both reversed-phase and hydrophilic interaction liquid chromatography (HILIC) separations, especially when large volumes are injected. Diluting the sample with weak solvent can be an effective solution to mitigate this problem, but we have to be careful to not lose analytes of interest to precipitation or phase separation.

Most manufacturers ship gas chromatographs with a small collection of consumable parts and accessories, such as extra ferrules, inlet liners, or septa, and a few instrument-specific tools. In earlier times, some convenience items might have been included as well, like a bubble flow meter or a small set of tools, but now it’s rare to find such things in the shipping boxes. This edition of “GC Connections” lists a number of essential items that should be on hand in every gas chromatography (GC) laboratory, their function, and how to use them effectively.

An excerpt from LCGC’s professional development platform, CHROMacademy.com

In this instalment of “GC Connections”, the advantages of multidimensional chromatography with HPLC as the first dimension and GC as the second are discussed.

The occurrence of additives, such as plasticizers in plastic food packaging, has been documented, but information on their potential migration into foods is limited. In this pilot study, 2D GC–MS was used to identify chemicals extracted from a common stretch plastic film with a series of organic solvents.

For decades the prevailing perception was that satisfactory re-equilibration of reversed-phase columns following gradient elution took a long time. In the early 2000s we showed that this perception was not well founded, and demonstrated that adequate re‑equilibration could be achieved in seconds. Recently, we have shown the same for HILIC columns. All of this work so far has been with small molecules. In this article, we present an overview of this work, and summarize the practical utility of it all.

The 16th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-16) will be held from 29–31 January 2020 in Ghent, Belgium.

An excerpt from LCGC’s professional development platform, CHROMacademy.com

Click the title above to open the Advances inBiopharmaceutical Analysis 2019 special issue in an interactive PDF format.

These three tips provide a clear starting point developing any HPLC method, to achieve optimum resolution in the minimum amount of time.

An introduction to this special issue by our guest editor

Keynote speaker Milton Lee of Brigham Young University presents “Portable Capillary Chromatography.”

Gulf Coast Conference keynote speaker Tyler Cohen Wood, who is an internationally recognized cybersecurity influencer and authority, presents “Cybersecurity-The New Frontier in Protecting Critical Infrastructure.”

Andy Boyd of the University of Houston presents “Data Handling and Analytics: A Case Study Using Airline Ticket Pricing as Told through Data and Deregulation.”

Hundreds of therapeutic mAbs and ADCs are in development. Detailed analytical characterization of these proteins is essential for ensuring product quality and safety. This LCGC ebook on Workflow Solutions for Optimizing Native ADC and mAb Analysis covers how advancements in SEC, HIC, and other techniques are helping analytics achieve better results.

I wanted to produce a checklist for preparation of a GC or GC–MS system prior to analysis, referencing the actions, checks, tools, and consumable items that might be required.

Incognito navigates the potentially precarious path to a successful relationship with a contract research organization (CRO).

The 9th International Symposium on Recent Advances in Food Analysis (RAFA 2019) will take place in Prague, Czech Republic, on 5–8 November 2019. This preview offers a glimpse of what to expect at the conference.

As I receive reports from clients in Europe and the United States that helium prices are once again increasing, and warnings are being given regarding yet another laboratory-grade helium shortage, my thoughts turn once again to the use of hydrogen as an alternative carrier-gas for gas chromatography (GC).

Knauer Wissenschaftliche Geräte GmbH has joined the European Union Funded IMPRESS research programme, whose goal is to advance the sustainable production of raw chemistry materials.

Thermo Fisher Scientific and Cedars-Sinai have announced a collaboration to develop a pathway to precision medicine through the development of robust, reliable, and sensitive LC–MS-based workflows for clinical research applications.

Researchers from the Technical University of Munich and the Leibniz-Institute for Food Systems Biology have developed a new method for the simultaneous analysis of odorants and tastants using UHPLC–MS.

Markes International Ltd were officially awarded two Queen’s Awards for Enterprise in September 2019.

Traveling to interesting places for conferences and hearing new ideas is certainly one of the most enjoyable aspects of a faculty position. Recently, I attended the 16th International Interdisciplinary Meeting on Bioanalysis (CECE 2019) in Gdansk, Poland. I was absolutely delighted both by the city and the scientific quality of the meeting.

Click the title above to open The Column October 2019 Europe & Asia issue, Volume 15, Number 10, in an interactive PDF format.

Click the title above to open The Column October 2019 North American issue, Volume 15, Number 10, in an interactive PDF format.

The 48th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2019), chaired by Alberto Cavazzini and Massimo Morbidelli, was held from 16–20 June in Milan, Italy. This instalment of “Column Watch” covers many of the highlights observed at the symposium.

The 13th International Scientific Conference on Ion Chromatography and Related Techniques will be held 21–22 April 2020 in Zabrze, Poland.