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To fully characterize a protein biopharmaceutical, it must be broken down into smaller segments (peptides). Several high performance liquid chromatography (HPLC) techniques can be used to provide a wealth of information on everything from post-translational modifications (PTMs) to the glycoprofile to information on similarity when characterizing biosimilars.

I run into scientists all the time who have never heard the term exposome. Most are not intimately connected in the analytical world; these days, analytical scientists seemingly expect “ome” and “omics” to be tacked onto pretty much anything.

Click the title above to open the LCGC Europe December 2019 regular issue, Volume 32, Number 12, in an interactive PDF format.

Click the title above to open the LCGC North America December supplement, Corporate Capabilities 2020, Volume 37, Issue s12, in an interactive PDF format.

Click the title above to open the LCGC North America December 2019 issue, Volume 37, Number 12, in an interactive PDF format.

Chromatographic peak integration continues to be a major regulatory issue and was first discussed in this column in 2015. Is the approach to manual intervention and manual integration outlined still acceptable in the light of regulatory citations and guidance documents published since then?

The 44th International Symposium On Capillary Chromatography (ISCC) and 17th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 24–29 May 2020.

This technical overview of chromatography data systems (CDS) looks at how CDS are designed, how they can be used most effectively, and what developments we can expect in the future.

The potential of food packaging components to migrate into food is an important health concern. Perfecto Paseiro Losada and his group at the University of Santiago de Compostela, in Spain, have been investigating the migration kinetics and actual migration of such compounds into a variety of types of food. They also have been carrying out studies to estimate dietary exposure. Paseiro recently spoke to LCGC about this work.

The 2020 winners of the LCGC Lifetime Achievement in Chromatography Award and the Emerging Leader Award have been selected.

In HPLC Diagnostics Skills Part I we looked at baseline issues, and we continue here with HPLC peaks and in particular the skills required to identify tailing peaks, the causes of peak tailing, and most importantly, how to fix the issues that give rise to this peak deformation.

Click the title above to open the LCGC Europe November 2019 regular issue, Volume 32, Number 11, in an interactive PDF format.

Theoretical computations can contribute input into experimental determinations.

Agilent Technologies has announced the opening of a new state-of-the-art facility for spectroscopy research and development at the Harwell Science and Innovation Campus in Oxfordshire, UK.

SepSolve Analytical Ltd has opened a state‑of‑the-art laboratory and training facility in Waterloo, Canada, to improve its service to North American customers.

Researchers attempting to overcome complex matrix interference in commercial food analysis have developed a targeted LC–MS/MS method and open source analysis software capable of identifying allergens in complex food matrices.

Sartorius Stedim Biotech (SSB) has agreed to acquire parts of Danaher’s Life Science portfolio.

Researchers have developed two new methods for the analysis of MOAHs in highly purified mineral oil fractions (white oils) using comprehensive AgLC×GC, one method uses FID, while the other uses VUV.

HTC-16 will be held from 29–31 January 2020 in Ghent, Belgium. This event preview offers a sneak peak of what to expect.

Kevin Schug delves into modern microscale liquid chromatography (LC) stationary phases.

Glycosylation is the most common monoclonal antibody (mAb) post‑translational modification. What is essential to know about it?

Click the title above to open The Column November 2019 North American issue, Volume 15, Number 11, in an interactive PDF format.

Click the title above to open The Column November 2019 Europe & Asia issue, Volume 15, Number 11, in an interactive PDF format.

Click the title above to open the LCGC Asia Pacific November/December 2019 regular issue, Vol 22, No 4, in an interactive PDF format.

Click the title above to open the LCGC North America November 2019 issue, Volume 37, Number 11, in an interactive PDF format.