How does one meet the most demanding part of an analysis-sampling? A typical example is soil, which presents a twofold problem for the analyst: first, the selection of the sites where the samples are taken, and second, the reduction of a sample (for example, 1 kg) to the analysis aliquot size (for example, 10 μL). This paper describes the details of sampling issues.
Here, we review the regulatory expectations of metrics for monitoring data integrity and discuss their practical implementation in a regulated chromatography laboratory.
Click the title above to open the LCGC North America October 2019 issue, Volume 37, Number 10, in an interactive PDF format.
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LCGC Europe spoke to Zhanfei Liu from the Marine Science Institute at the University of Texas at Austin, Texas USA, about the advantages of ramped pyrolysis GC–MS to analyze petroleum pollution from the Deepwater Horizon oil spill.
Pharmaceutical Product Development (PPD) is expanding its bioanalytical laboratory in Richmond, Virginia, in an effort to enhance its ability to meet biopharmaceutical clients’ increasing research needs.
Click the title above to open the LCGC Europe September 2019 regular issue, Volume 32, Number 9, in an interactive PDF format.
The 9th International Symposium on Recent Advances in Food Analysis (RAFA 2019) will take place in Prague, Czech Republic, on 5–8 November 2019. This preview offers a glimpse of what to expect at the conference.
This article discusses the detection of N-nitroso compounds (NOC) in a range of different food and beverages.
The Chromatographic Society (ChromSoc) will be hosting the 4th “Grass Roots” educational event at the Longmynd Hotel in the beautiful market town of Church Stretton from the 4–7 October 2019.
Researchers from the University of Rome have developed a strategy for the identification of underivatized short peptides in urine using graphitized carbon black (GCB) solid-phase extraction (SPE) and liquid chromatography–mass spectrometry (LC–MS).
The first Analytica Lab Africa took place this July at the Gallagher Convention Center in Johannesburg with 148 exhibitors from 15 countries presenting their products and solutions for the African market.
Click the title above to open The Column September 2019 North American issue, Volume 15, Number 9, in an interactive PDF format.
Click the title above to open The Column September 2019 Europe & Asia issue, Volume 15, Number 9, in an interactive PDF format.
In an effort to better understand the current application potential of microscale liquid chromatography (micro-LC), I picked up a few recent review articles from the literature. What one immediately appreciates from glancing through the literature for such information, is that there are a lot of different configurations and alternative formats, which can be placed under the micro-LC umbrella.
Click the title above to open the LCGC Asia Pacific August/September 2019 regular issue, Vol 22, No 3, in an interactive PDF format.
Click the title above to open the LCGC North America September 2019 issue, Volume 37, Number 9, in an interactive PDF format.
Superficially porous particles have demonstrated separation efficiency gains compared to totally porous particles. The total pore blocking technique provides the purest possible measure of column packing quality. Here, we explain this technique and show what it has revealed.
Glycosylation is the most common monoclonal antibody (mAb) posttranslational modification. What is essential to know about it?
Are EU GMP Chapter 4 and USP Chapter on Good Documentation Guidelines similar or complementary? Should we consider any other sources of advice?
In on-site environmental applications, representative sampling and proper replication are essential. For these reasons, recent work in thin-film solidphase microextraction has focused on the development of unique holders and customized samplers that are tailored for distinct sampling environments. Here, we explore the latest developments.
The sample solvent can have a big impact on peak shape in both reversed-phase and hydrophilic interaction liquid chromatography (HILIC) separations, especially when large volumes are injected. Diluting the sample with weak solvent can be an effective solution to mitigate this problem, but we have to be careful to not lose analytes of interest to precipitation or phase separation.
Most manufacturers ship gas chromatographs with a small collection of consumable parts and accessories, such as extra ferrules, inlet liners, or septa, and a few instrument-specific tools. In earlier times, some convenience items might have been included as well, like a bubble flow meter or a small set of tools, but now it’s rare to find such things in the shipping boxes. This edition of “GC Connections” lists a number of essential items that should be on hand in every gas chromatography (GC) laboratory, their function, and how to use them effectively.
The 9th International Symposium on Recent Advances in Food Analysis (RAFA 2019) will take place in Prague, Czech Republic, on 5–8 November 2019.