Mass Spectrometry

A study has proposed targeted methods, developed using gas chromatography coupled to tandem mass spectrometry, to measure human plasma protein binding and hepatocyte clearance in 73 per- and polyfluoroalkyl substances, or PFAS.

Microextraction using sustainable green solvents, followed by mass spectrometric analysis, comprise a combined approach that is still in its infancy.

Joycelyn Tan, a PhD candidate at the University of Cambridge, is the 2024 recipient of the Darlene Solomon Award, co-sponsored by Females in Mass Spectrometry and Agilent Technologies, and created to provide support for up-and-coming women scientists.

A recent review article highlights the current analytical techniques being used to detect illicit drug use in sports.

At the 2024 Pittcon Conference, Elizabeth Humston-Fulmer of LECO Corporation presented an improved workflow which uses two-dimensional gas chromatography (GCxGC) with dual time of flight (TOF) MS/FID detection. Shortly after Pittcon, Humston-Fulmer discussed this analytical method with us.

Scientists recently tested a new system for detecting and extracting favipiravir from plasma samples.

Conventional sample preparation can be time- and resource-consuming, and a green analytical methodology can be a game-changer for scientists, in addition to facilitating selective and sensitive separations.

A recent article examines how the coupling of liquid or gas chromatography to mass spectrometry has advanced the development dielectric barrier discharge ion sources.

Limited toxicokinetic and toxicologic information is available about a diverse set of per- and polyfluoroalkyl substances (PFAS), but methods based on gas chromatography–tandem mass spectrometry (GC–MS/MS) can help unravel some of the mystery.

Scientists from the Affiliated Hospital of Putian University recently analyzed the dysregulation of lipid metabolism in patients suffering from chronic hepatitis B patients.

Joycelyn Tan of the University of Cambridge recently won the Darlene Solomon Award for her notable research into mass spectrometry.

The company’s new service will provide expedited testing to customer around the world.

This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!

A recent study examined using high performance liquid chromatography coupled to mass spectrometry (HPLC–MS/MS) to optimize this key class of drugs that are used for the treatment of the common cold and flu.

In this review article, we showcase some of LCGC International’s recent coverage of mass spectrometry.

In a recent study from the GITAM School of Pharmacy, two scientists used different liquid chromatography techniques to assess the properties of ozenoxacin (OXC) and its degradation products.

Scientists investigated using this method to measure volatile organic compounds in the breath of patients with chronic kidney disease.

A multidisciplinary study was conducted to increase our understanding of thiosuccinimide linkers in bioconjugates.

In a recent study, researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College used liquid chromatography–mass spectrometry (LC–MS) to gain further insight into tumor metabolism.

In a recent study out of Central South University in Changsha, China, scientists tested different cosine similarity algorithms to test for illegal adulterants in drugs.

Here are the top five articles that the editors of LCGC International published this week.

In a recent study, scientists tested how effective dynorphin 1-17 peptides can be in treating chronic rhinosinusitis with nasal polyps (CRSwNP).

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A recent study dissects a Chinese herbal medicine to determine why it is effective in treating polycystic ovary syndrome (PCOS).

At Pittcon 2024, LCGC International editor Patrick Lavery sat down with Michael Marty of the University of Arizona to talk about the ongoing work in his laboratory.

At Pittcon 2024, LCGC International editor Patrick Lavery sat down with Susan Olesik of The Ohio State University to talk about her group’s current work.

A group of Canadian scientists recently measured how effective different solutions are in measuring ochratoxin A levels in flour samples.

This article explores the key challenges analytics and mass spectrometry solve within the biopharmaceutical industry.

The advantages of a native anion exchange method coupled to mass spectrometry for charge heterogeneity analysis of immunoglobulin G4 (IgG4)-based mAbs are described.