July 26th 2024
Here are the top five articles published on LCGC International this week.
Analyzing Quality Markers of Processed Qingpi: A Comprehensive Approach
February 9th 2024Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.
Comprehensive Analysis Unveils Chemical Composition of Lingbao Huxin Dan for Cardiovascular Health
February 7th 2024Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.
Scientists Reveal New Method for Soil Pesticide Detection Based on UHPLC-MS/MS
February 1st 2024Scientists in Mexico developed a new method for detecting herbicides in agricultural soil, being based on techniques like 9-fluorenylmethyl chloroformate (FMOC-Cl) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
Q&A: Unraveling the Dynamics of GM3 Gangliosides in Human Milk Across Lactation Stages
February 1st 2024Weronika Hewelt-Belka, an assistant professor at Gdańsk University of Technology in Poland, answers questions about her research analyzing GM3 gangliosides in human milk, elucidating their molecular distribution and dynamic changes throughout lactation.
Inside the Laboratory: The Yang Group of the University of Oklahoma
January 16th 2024In our second edition of “Inside the Laboratory,” Zhibo Yang, PhD, an associate professor of chemistry at the University of Oklahoma, discusses his group’s most recent work in single-cell mass spectrometry (MS) and MS tissue imaging.
Synthesizing Synthetic Oligonucleotides: An Interview with the CEO of Oligo Factory
January 15th 2024LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.
This review article discusses scientific rationales and current best practices in the pharmaceutical industry for performing chromatographic peak purity assessments (PPA). These activities are associated with the development and validation of liquid chromatographic (LC) stability-indicating analytical methods applicable to regulatory submissions of small-molecule drug candidates. The discussion includes a comprehensive overview of the PPA-related regulatory and scientific landscape and common industry approaches to obtain PPA results, as well as the strengths and weaknesses of PDA-facilitated ultraviolet (UV) PPA and other PPA techniques.