April 26th 2024
Here are the top five articles that the editors of LCGC International published this week.
Imaging Mass Spectrometry with Gas-Phase Charge Inversion Ion/Ion Reaction Separates Isobaric Lipids
October 16th 2023Researchers from the University of Florida have employed gas-phase charge inversion ion/ion reactions to distinguish isobaric lipids in imaging mass spectrometry, offering enhanced molecular specificity for analyte identification.
Two IMS-MS Modalities Assist Nonenzymatic Posttranslational Modification Studies Without Mass Loss
October 13th 2023Researchers at two US colleges have utilized ion mobility spectrometry–mass spectrometry (IMS-MS) to analyze nonenzymatic posttranslational modifications and peptide cleavages in a single peptide system, revealing insights into critical biomarkers for age-related diseases.
Q&A: FDA Talks to LCGC About Chromatographic Techniques for PFAS Detection in Food Supply
October 13th 2023FDA scientists have expanded the number of analytes in their analytical method for per- and polyfluoroalkyl substances (PFAS), partly in response to updated guidance out of the European Union (EU) on method parameters and limits of quantification (LOQs).
AIU–IM–MS Unlocks Precision in Assessing Therapeutic Antibody Stability
October 12th 2023Researchers in Tianjin, China, have employed all ion unfolding–ion mobility–mass spectrometry (AIU–IM–MS) to enhance the differentiation of therapeutic polyclonal antibodies, offering insights into improvements in conformational stability and advantages in cost-effectiveness.
Advances in Liquid Chromatography for Mustard Agent Exposure Biomonitoring Revealed
October 10th 2023Valérie Pichon's review in Analytical and Bioanalytical Chemistry delves into sophisticated liquid chromatography techniques for detecting albumin adducts, vital biomarkers in retrospective mustard agent exposure monitoring, offering a broader window of detection than urine-based methods.
New 2D LC–MS Analytical Method Unveils the Secrets of Ancient Chinese Herbal Formula HGWD
October 10th 2023A comprehensive analytical approach utilizing online two-dimensional liquid chromatography coupled with hybrid linear ion trap orbital trap mass spectrometry, has enabled the in-depth analysis of Huangqi Guizhi Wuwu decoction, identifying 170 chemical constituents and offering insights into its complex chemical composition and potential therapeutic properties.
Why is Open-Access Hyphenation Important for Chromatographers?
October 4th 2023At HPLC 2023, John Langley, a professor at the University of Southampton in Southampton, UK, presented a talk called "(R)evolution of Hyphenations, Through Open-Access RP-HPLC–MS, Open-Access UHPSFC–MS and 2D-LC–IMS-MS in Academia". He spoke with LCGC on the importance of open-access hyphenation, and how to implement it in your research.
Scientists used supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—to analyze various types of chlorinated paraffins (CPs) in fish oil-based dietary supplements.
Multitargeted Internal Calibration Using LC–MS Quantifies Chronic Kidney Disease-Linked Metabolites
September 30th 2023Researchers have developed a multitargeted internal calibration method for precise quantification of chronic kidney disease (CKD)-related endogenous metabolites using liquid chromatography–mass spectrometry (LC–MS).