Mass Spectrometry

Vaughan Langford discusses the application of automated selected ion flow tube mass spectrometry (SIFT-MS) analysis to diverse high-throughput food analysis applications, including sensory-correlated analysis, authentication, and ingredient screening.

High-end mass spectroscopy innovation is driven by proteomics, leaving scientists in other fields like drug development, environmental analysis, and metabolomics underserved.

Ionic liquids (ILs) are structurally tunable salts that pose unique analytical challenges.Ionic liquids (ILs) are structurally tunable salts that pose unique analytical challenges. This article reviews how mass spectrometry is used to study IL ion clusters, dissociation pathways, and decomposition products, with a focus on applications in spacecraft propulsion and environmental contamination.

Webinar Date/Time: Wednesday, May 27 and Thursday, May 28, 2026 Morning Session: 9:00 AM EDT Lunchtime Session: 12:00 PM EDT Afternoon Session: 1:00 PM EDT

Μetabolomics enables the comprehensive profiling of small molecules in medicine, plant science, and systems biology. Its true value depends not on the number of detected features but on the reliability of metabolite identification and pathway analysis. Despite well-established guidelines, annotation and definitive identification are often conflated in practice. Simple matches in mass databases are frequently reported as identities, without comparison to standards or chromatographic evidence. This overstatement of confidence compromises validity and risks propagating errors into databases, pathway analyses, and AI-driven workflows. Mass spectrometry (MS) alone is rarely sufficient for identification and orthogonal evidence is essential. Chromatographic retention time is an underused but powerful descriptor reflecting molecular properties. When combined with MS it can provide plausibility checks and form the basis of Level 1 identification. Regulatory frameworks already require such combined criteria in targeted analysis. Systematic use of retention order, retention indices, and prediction models can filter implausible candidates and strengthen identification.

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.

Webinar Date/Time: Tuesday, March 17 and Wednesday, March 18, 2026 Morning Session: 9:30 AM EDT | 1:30 PM GMT | 2:30 PM CET Afternoon Session: 12:00 PM EDT | 4:00 PM GMT | 5:00 PM CET

Webinar Date/Time: Thursday, March 19, 2026 8am PST | 11am EST | 4pm GMT | 5pm CET

Webinar Date/Time: Thu, Feb 26, 2026 12:00 PM EST

Webinar Date/Time: Thursday, February 19, 2025 8am PST | 11am EST | 4pm GMT | 5pm CET

Webinar Date/Time: Tue, Jan 20, 2026 11:00 AM EST

Selected ion flow tube mass spectrometry (SIFT-MS) offers potential for rapid screening of volatile nitrosamines and their amine precursors in a single run.

High-throughput mass spectrometry (HT-MS) is becoming a driving force in modern drug discovery. This article explains how a purpose-built digital ecosystem—featuring structured data, automation, artificial intelligence (AI)-driven analytics, and cloud scalability—is essential to translate massive HT-MS data sets into reproducible, actionable decisions.

Webinar Date/Time: Monday, December 8, 2025 8am PST | 11am EST | 4pm GMT | 5pm CET

Chip Cody discusses his work in mass spectrometry, including DART ion source innovations and insights on chromatography integration.

Webinar Date/Time:Wednesday December 3rd 2025 Morning Session: 9:15am EST | 6:15am PST | 2:15pm GMT | 3:15pm CEST Afternoon Session: 11:45am EST | 8:45am PST | 4:45pm GMT | 5:45pm CEST Thursday December 4th 2025 Morning Session: 9:15am EST | 6:15am PST | 2:15pm GMT | 3:15pm CEST Afternoon Session: 11:15am EST | 8:15am PST | 4:15pm GMT | 5:15pm CEST

Webinar Date/Time: Tue, Nov 18, 2025 11:00 AM EST

Webinar Date/Time: Thursday, November 20, 2025 8am PDT | 11am EDT | 4pm GMT | 5pm CET Thusrsday December 4th 2025: The State of The Art in Pharmaceutical Analysis: A Virtual Symposium Time: 9:15 am EDT/2:15 pm GMT/3:15 pm CET

This week, LCGC International published a variety of articles on hot topics in separation science. From an interview about the latest advancements in supercritical fluid chromatography (SFC), a news article about a new product from Thermo Fisher, and an article about bioanalytical liquid chromatography–mass spectrometry (LC–MS), we’ve highlighted some of the most popular articles that were published this week.

Webinar Date/Time: Thu, Oct 23, 2025 10:00 AM EDT

Thermo Fisher’s Chromeleon 7.4 centralizes chromatography and mass spectrometry workflows with networked access and data management.

Top-down proteomics offers a new window into the true complexity of protein species and promises to complement, rather than replace, traditional bottom-up methods. Here, we explore these developments and what the future might hold.

This article reviews SIFT-MS odor analysis in food-flavor, packaging, and environmental applications, suggesting potential utilization as an objective screening tool.

The concept of dark omics refers to the significant proportion of uncharacterized molecular features within complex biological samples that are often present yet remain inaccessible or unidentified by conventional analytical techniques. This article explores how ion mobility spectrometry integrated with mass spectrometry (IM‑MS) provides critical solutions to longstanding challenges in accessing these dark regions across metabolomics, proteomics, lipidomics, and emerging areas, such as exposomics.

Webinar Date/Time: Wed, Oct 22, 2025 11:00 AM EDT