Application Notes: General

Oligonucleotides were then analyzed using liquid chromatography with ultraviolet and mass spectrometry with a polymer-based diol column.

SGS AXYS and Waters validated GC–MS/MS as an alternative procedure to HRMS, and adapted EPA Method 1613B criteria, proving equivalency in results and performance metrics.

This application note demonstrates a reliable SPE method with an automated SPE system for the determination of PFAS in drinking water per U.S. EPA Method 533.

Reliable SPE for PFAS in drinking water per U.S. EPA Method 537.1

This application note presents a simple HILIC-RI method for the analysis of four common sugars found in maple syrup, utilizing an LC 300 HPLC with Refractive Index detector.

This application demonstrates a fast, robust, and sensitive HPLC method for the analysis of eight parabens in commercially available cosmetic and personal care products.

Efficient and reliable UHPLC method for the analysis of 12 isoflavones, prepared in accordance with the USP monograph for soy, using an LC 300 with PDA detector.

AOAC Method 2001.02 for TGOS analysis executed with a Thermo Scientific Dionex CarboPac PA1-1mm column using HPAE-PAD in Dual EGC Mode.

AOF by combustion IC – non-targeted complemental determination of PFAS in aqueous samples

This application note demonstrates dual eluent generation cartridge performance for profiling galactosyl-oligosaccharides using HPAE-PAD.

Thermo Scientific Dionex CarboPac PA300-4µm column allows simplified, high-resolution sorbitol separation and quantification in complex samples.

This work describes a simple and fast method for the analysis of sixteen commonly analyzed cannabinoids utilizing a PerkinElmer LC 300 HPLC with PDA detector.

This application note demonstrates how Norma Oficial Mexicana for agave syrup carbohydrate analysis is executed with a Thermo Scientific Dionex CarboPac PA1-1 mm column using HPAE-PAD in EGC mode.

Nitrosamines are potentially dangerous genotoxic compounds that have been recently found within some pharmaceutical products. We demonstrate highly sensitive methods to accurately detect and quantify these compounds.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC–MS/MS for measuring pesticides in spinach purchased from local grocers is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in honey purchased from local apiaries is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in kale purchased from local grocers is described in this application note.

Combining high-resolution size exclusion chromatography columns with highly sensitive MALS detection characterizes oligonucleotides and structurally-related impurities.

This technical note explores a new trityl-on procedure that minimizes the risk of depurination.

This application note presents a case study for metabolite profiling of model pharmaceutical compounds using HRAM MS and small molecule ID software for data processing.

Extraction of oligo therapeutics from biological samples for LC–MS bioanalysis

Using the Clarity OTX extraction protocol vendor recommendations, we have demonstrated its use to develop a method for the extraction of therapeutic oligos from plasma.

Historically, helium has been used as a makeup or carrier gas. Learn about the disadvantages of helium and why so many laboratories are switching to nitrogen gas for GC.

This technical note discusses 2' cleavage and RNA sample preparation prior to trityl-on Clarity QSP cartridge or high-throughput purification.

As synthetic oligonucleotide therapeutics traverse the drug-development path, there is an increasing need for TK and PK/PD studies in drug discovery and development.

Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.