Application Notes: General

Detection of eight metabolites of benzodiazepines are achieved in under 10 minutes. Both glucuronide forms and parent compounds are observed by UV HPLC.

This application note shows the LC–MS analysis of multiresidue pesticides. Quantification, linearity, and matrix recovery limits are shown for the pesticide compounds.

This application note shows the LC–MS analysis of multiresidue pesticides. Quantification, linearity, and matrix recovery limits are shown for the pesticide compounds.

Good retention and peak shape for Atorvastatin is observed on Quasar AQ phase in this application.

The separation and identification of 16 common drug substances is possible in the field using a combination of a portable GC/MS in under 10 min.

The Quasar SPP C18 HPLC phase offers high efficiency separation of the anti-inflammatory drug, naproxen.

Fentanyl, acetyl fentanyl, carfentanil, and heroin were collected and identified using CME syringes with our portable GC–MS in drug screening scenarios.

This application looks at the differences in chromatography between the Quasar C18 and AQ phase chemistries for the analysis prednisolone, prednisone, and cortisone.

This technique achieves highly reproducible and fast analysis of organochlorine pesticides in water by coupling automation with the use of a disperser solvent.

The Eclipse Neutrino, a premier monomer analyzer process gas chromatograph, couples MSD, PDHID, and FID detectors to characterize an extremely broad range of analytes from fixed gases to C5+. Quickly detecting ppm-ppb levels of impurities and catalyst poisons.

Robust and accurate primary sequence confirmation and monitoring of post-translational modifications of the SARS-CoV-2 spike protein using the BioAccord LC–MS system.

Eliminate the need for column conditioning, improve recovery, and improve repeatability by minimizing non-specific oligonucleotide interactions with metal surfaces.

A rapid, sensitive, and reproducible method for understanding the SARS-CoV-2 spike protein N-glycosylation profile using the GlycoWorks RapiFluor MS N-Glycan Kit.

Review of the best practices for oligonucleotide analysis and purification to achieve high quality oligonucleotides for COVID-19 diagnostic or therapeutic applications.

A HILIC method for baseline separation of ribavirin from isobaric and structurally similar species within 6 minutes using an ACQUITY UPLC BEH Amide column.

This work demonstrates how to achieve sharper peaks and faster elution of basic analytes like umifenovir using a mixed-mode Atlantis PREMIER BEH C18 AX column.

We discuss the role of LC and LC–MS for select COVID-19 applications to better understand the use of analytical technologies mobilized in the fight against the pandemic.