Application Notes: General

Extraction of oligo therapeutics from biological samples for LC–MS bioanalysis

Using the Clarity OTX extraction protocol vendor recommendations, we have demonstrated its use to develop a method for the extraction of therapeutic oligos from plasma.

Historically, helium has been used as a makeup or carrier gas. Learn about the disadvantages of helium and why so many laboratories are switching to nitrogen gas for GC.

This technical note discusses 2' cleavage and RNA sample preparation prior to trityl-on Clarity QSP cartridge or high-throughput purification.

As synthetic oligonucleotide therapeutics traverse the drug-development path, there is an increasing need for TK and PK/PD studies in drug discovery and development.

Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.

This technical note discusses a simple, yet quick and effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit.

Advance your oligonucleotide work, from sample preparation to analysis and purification

To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.

This eBook covers the most common EPA regulations and methods analytical laboratories employ to meet the challenges of VOC analysis for environmental samples.

Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence.

This guide for routine beverage analysis demonstrates essential testing with one analyzer. Learn more about fast turnaround, reduced human error, and reduced reagent use.

This application note demonstrates the quantitative analysis of microplastics using direct thermal desorption (TD) combined GC–MS.

In this technical note we explore column miniaturization effects attained by reducing column ID from 300 μm to 75 μm and its effects on sensitivity.

Impact of sub-2 μm fully porous particles and core-shell particles in nano LC–MS evaluated by separation performance and protein and peptide identifications in proteomics.

How to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed phase fractionation strategy in combination with nano flow LC–MS

In this application note we explore the effects of trap loadability using a bioZen 3 μm Polar C18 nano column in conjunction with the bioZen RP1 (C18) nano trap column.

In this technical note we show peptides and proteins identified using the bioZen nano XB-C18 column in either direct inject or trap and elute mode.

The effect of column selectivity and its importance in the quality of data achieved in protein and peptide identifications in bottom-up proteomics applications is demonstrated.

In this application, we show reproducible results across multiple columns as well as the robust ability of the bioZen 2.6 μm XB-C18 column after 100 injections.

A miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.