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We demonstrate how to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed-phase fractionation strategy in combination with nano flow LC–MS.

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We demonstrate how to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed-phase fractionation strategy in combination with nano flow LC–MS.

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The bioZen high pH fractionation HPLC column provides superior performance using titanium hardware, minimizing nonspecific adsorption for peptide identifications.

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In this technical note we explore column miniaturization effects attained by reducing column ID from 300 μm to 75 μm and its effects on sensitivity.

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In this application we show reproducible results across multiple columns as well as the robust ability of the bioZen 2.6 μm XB-C18 column after 100 injections.

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Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

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Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

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In reference to the Japanese Pharmacopeia, YMC-Triart Bio C18 was used to analyze the peptide leuprorelin (GnRH analogue) and separate it from its degradation products.

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In this application note, YMC’s dedicated SEC column for antibodies, YMC-SEC MAB, has been used to develop a method for bevacizumab using MALLS detection.

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Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

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Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column ensuring symmetric peaks, high sensitivity, and no carryover effects.

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The antibody-drug conjugate was separated from its aggregates and fragments in only one run using a YMC-SEC MAB column and varying mobile phases.

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In this application note, the DAR of the SigmaMAb ADC-mimic was determined using YMC’s BioPro HIC BF column and a nanospray ionization mass spectrometer.

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IONICON real-time VOC analyzers are frequently deployed in mobile laboratories, contributing to public safety, tracking air pollution where and when it matters.



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The unique design of the 50 cm μPAC™ GEN2 nanoLC column provides superior performance over state-of-the-art packed bed columns, achieving peak capacities of over 1000.



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Here we present a mycotoxin screening method for beer grain and beer samples utilizing a HALO PFP column, which enables high sensitivity, high resolution, and high-speed separations for this analysis.

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The use of headspace sorptive extraction with GC×GC–TOF-MS to compare the volatile profiles of ground meat and plant-based substitutes.

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Discover a reliable and robust HPLC method to separate Δ10-THC and Δ6a,10a-THC isomers produced from Δ9-THC degradation using a chiral HPLC stationary phase.

See chiral separations for anti-viral COVID-19 treatment Remdesivir and its phosphoramidite and nucleoside key-starting materials, on Daicel chiral and achiral columns.

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In EPA 524.3, environmental labs are allowed to modify purge and trap/GC-MS conditions for drinking water samples. CDS 7000 series product meets and exceeds the requirements.

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In EPA 524.4, nitrogen replaced helium in purging VOCs from drinking water samples. CDS 7000 concentrator with a 7450 autosampler meets and exceeds the requirements.