Application Notes: General

Mipomersen (Kynamro®) is used as a model for the analysis of antisense oligonucleotides (ASOs) using LC-HRMS. The YMC-Triart C8 metal-free column used is an excellent choice for oligonucleotides.

This application note demonstrates the use of supercritical fluid chromatography (SFC) to separate highly polar and even ionic compounds.

This application note demonstrates the use of supercritical fluid chromatography (SFC) to separate highly polar and even ionic compounds.

This application note reviews how multi-angle and dynamic light scattering provide accurate, precise measurements of the biophysical attributes of AAV gene vectors.

Learn how SEC coupled to multi-angle light scattering and viscometric detectors determines absolute molar mass, size and conformation of highly complex biopolymers.

Daicel’s CHIRALPAK® IJ gives access to an expanded range of solvents, which yields new separations not previously achievable on the coated CHIRALCEL® OJ.

A SLE application for acids (THC-COOH), neutrals (barbiturates), and bases (Norbuprenorphine and Buprenorphine) from a urine matrix containing β-glucuronidase followed by two LC-MS/MS methods.

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE for less background noise and cleaner samples post sample preparation.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum

Testosterone was isolated from plasma using Novum PRO 96-Well Plates SLE sample preparation.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

A sensitive method for analyzing nicotine and metabolites using SLE to increase recoveries, while still displaying accuracy, precision and linearity.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Peptides are extracted from plasma comparing Strata-X PRO SPE to two types of ion exchange polymeric sorbent. Strata-X PRO provides high recoveries with a fast and effective clean-up method.

Profiling of whiskeys in the Lucidity miniGC shows alcohol content as well as the amount of seven other interesting compounds that add flavor and aroma to the whiskeys.

The profiling of edible oils in the Lucidity miniGC, allows users to confirm the type of oil and measure the amounts of saturation of the different components of the oil.

Thermo Scientific™ Gallery™ analyzers are sophisticated discrete photometric systems for the precise and easily adaptable analysis of water and environmental samples.