
Application Notes: General


This application note shows the LC–MS analysis of multiresidue pesticides. Quantification, linearity, and matrix recovery limits are shown for the pesticide compounds.


This application note shows the LC–MS analysis of multiresidue pesticides. Quantification, linearity, and matrix recovery limits are shown for the pesticide compounds.










Good retention and peak shape for Atorvastatin is observed on Quasar AQ phase in this application.

The separation and identification of 16 common drug substances is possible in the field using a combination of a portable GC/MS in under 10 min.

The Quasar SPP C18 HPLC phase offers high efficiency separation of the anti-inflammatory drug, naproxen.

Fentanyl, acetyl fentanyl, carfentanil, and heroin were collected and identified using CME syringes with our portable GC–MS in drug screening scenarios.

This application looks at the differences in chromatography between the Quasar C18 and AQ phase chemistries for the analysis prednisolone, prednisone, and cortisone.

This technique achieves highly reproducible and fast analysis of organochlorine pesticides in water by coupling automation with the use of a disperser solvent.

The Eclipse Neutrino, a premier monomer analyzer process gas chromatograph, couples MSD, PDHID, and FID detectors to characterize an extremely broad range of analytes from fixed gases to C5+. Quickly detecting ppm-ppb levels of impurities and catalyst poisons.

Comprehending COVID-19: Preliminary Examination of the SARS-CoV-2 Spike Protein by Peptide Mapping
Robust and accurate primary sequence confirmation and monitoring of post-translational modifications of the SARS-CoV-2 spike protein using the BioAccord LC–MS system.

Improved Chromatographic Analysis of Oligonucleotides with ACQUITY PREMIER Oligonucleotide BEH C18 Columns
Eliminate the need for column conditioning, improve recovery, and improve repeatability by minimizing non-specific oligonucleotide interactions with metal surfaces.

Comprehending COVID-19: Rapid and Sensitive Characterization of N-Glycans from SARS-CoV-2 Spike Protein
A rapid, sensitive, and reproducible method for understanding the SARS-CoV-2 spike protein N-glycosylation profile using the GlycoWorks RapiFluor MS N-Glycan Kit.

Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatography – Columns and Chemistries
Review of the best practices for oligonucleotide analysis and purification to achieve high quality oligonucleotides for COVID-19 diagnostic or therapeutic applications.

Comprehending COVID-19: Fast Analysis of Ribavirin and Related Compounds Using Hydrophilic Interaction Chromatography
A HILIC method for baseline separation of ribavirin from isobaric and structurally similar species within 6 minutes using an ACQUITY UPLC BEH Amide column.

Comprehending COVID-19: Using the Atlantis PREMIER BEH C18 AX Mixed-Mode Column for the Analysis of Umifenovir
This work demonstrates how to achieve sharper peaks and faster elution of basic analytes like umifenovir using a mixed-mode Atlantis PREMIER BEH C18 AX column.

We discuss the role of LC and LC–MS for select COVID-19 applications to better understand the use of analytical technologies mobilized in the fight against the pandemic.

The evaluation of different salt gradients was performed on the Agilent 1290 Infinity II Bio LC System and analyzed for resolution as well as reproducibility.

This application note demonstrates the DAR determination of brentuximab vedotin using HIC. Excellent reproducibility was found with the Agilent 1290 Infinity II Bio LC.